Target Name: LMNB1
NCBI ID: G4001
Review Report on LMNB1 Target / Biomarker Content of Review Report on LMNB1 Target / Biomarker
LMNB1
Other Name(s): Lamin B1 | lamin-B1 | Lamin B1, transcript variant 2 | lamin B1 | LMN | LMNB | LMNB1 variant 1 | CDNA FLJ50934, highly similar to Lamin-B1 (isoform 2) | Lamin-B1 (isoform 1) | LMNB1 variant 2 | Lamin B1, transcript variant 1 | ADLD | LMN2 | Lamin-B1 | MGC111419 | LMNB1_HUMAN | MCPH26

LMNB1: A Protein Involved in Cell Membrane Integrity and Neurodegenerative Diseases

LMNB1, or laminin 1, is a protein that is expressed in various tissues throughout the body, including the brain, spinal cord, and heart. It is a member of the family of transmembrane proteins, which means that it spans the cell membrane and extends into the cytoplasm. Laminin proteins are involved in the structure and function of many different tissues and are thought to play a role in the development and progression of many diseases.

One of the functions of laminin proteins is to help maintain the integrity of cell membranes. This is important for maintaining the structural and electrical properties of cells and is also involved in the regulation of various signaling pathways. Laminin proteins can also play a role in the regulation of cell growth and the development of tissues.

LMNB1 is a 21-kDa protein that is expressed in the brain and is thought to be involved in the development and maintenance of the myelin sheath that surrounds and protects nerve fibers in the central nervous system. It is also expressed in other tissues, including the heart and is involved in the regulation of various signaling pathways.

One of the key functions of LMNB1 is its role in the regulation of the myelin sheath. Myelin is a protein that is produced by the Schwann cells, which are the glial cells that support and protect nerve fibers in the central nervous system. Myelin is responsible for maintaining the electrical properties of the nervous system and is thought to play a role in the regulation of pain and other neurological conditions.

Research has suggested that LMNB1 may be a drug target or biomarker for the treatment of various neurological and psychiatric disorders. For example, LMNB1 has been shown to be involved in the regulation of neurotransmitter release from nerve axons and to play a role in the development of neurodegenerative diseases. Additionally, LMNB1 has been shown to be involved in the regulation of pain perception and the modulation of pain modalities.

LMNB1 may also be a potential biomarker for certain psychiatric disorders. For example, LMNB1 has been shown to be involved in the regulation of the release of various neurotransmitters, including dopamine and serotonin, which are involved in the regulation of mood and other psychiatric symptoms. Additionally, LMNB1 has been shown to be involved in the regulation of the activity of various G protein-coupled receptors, which are involved in the regulation of various physiological processes, including mood regulation.

In conclusion, LMNB1 is a protein that is involved in the regulation of various physiological processes and is thought to play a role in the development and progression of many diseases. Its role in the regulation of the myelin sheath and the regulation of neurotransmitter release from nerve axons makes it a potential drug target or biomarker for the treatment of various neurological and psychiatric disorders. Further research is needed to fully understand the role of LMNB1 in these processes and to develop effective treatments for these disorders.

Protein Name: Lamin B1

Functions: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin

The "LMNB1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LMNB1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

LMNB2 | LMNTD1 | LMNTD2 | LMNTD2-AS1 | LMO1 | LMO2 | LMO3 | LMO4 | LMO7 | LMO7-AS1 | LMO7DN | LMOD1 | LMOD2 | LMOD3 | LMTK2 | LMTK3 | LMX1A | LMX1B | LMX1B-DT | LNC-LBCS | LNCAROD | LNCARSR | LNCATV | LNCNEF | LNCOC1 | LNCOG | LNCPRESS1 | LNCRI | LNCRNA-ATB | LNCRNA-IUR | LNCTAM34A | LNP1 | LNPEP | LNPK | LNX1 | LNX1-AS1 | LNX2 | LOC100127946 | LOC100127955 | LOC100128002 | LOC100128028 | LOC100128050 | LOC100128059 | LOC100128079 | LOC100128093 | LOC100128164 | LOC100128242 | LOC100128288 | LOC100128317 | LOC100128361 | LOC100128398 | LOC100128494 | LOC100128593 | LOC100128770 | LOC100128966 | LOC100128988 | LOC100129034 | LOC100129098 | LOC100129148 | LOC100129175 | LOC100129203 | LOC100129215 | LOC100129316 | LOC100129381 | LOC100129434 | LOC100129455 | LOC100129534 | LOC100129603 | LOC100129697 | LOC100130000 | LOC100130207 | LOC100130285 | LOC100130298 | LOC100130331 | LOC100130452 | LOC100130463 | LOC100130548 | LOC100130587 | LOC100130691 | LOC100130698 | LOC100130744 | LOC100130748 | LOC100130872 | LOC100130899 | LOC100130938 | LOC100130987 | LOC100130992 | LOC100131096 | LOC100131107 | LOC100131257 | LOC100131289 | LOC100131372 | LOC100131496 | LOC100131532 | LOC100131626 | LOC100131635 | LOC100131859 | LOC100131877 | LOC100131943 | LOC100132004