Target Name: LOC100128398
NCBI ID: G100128398
Review Report on LOC100128398 Target / Biomarker Content of Review Report on LOC100128398 Target / Biomarker
Other Name(s): Uncharacterized LOC100128398 | uncharacterized LOC100128398

Introduction About LOC100128398

LOC100128398, also known as LINC00649, is an intriguing gene that has been gaining significant attention as both a potential drug target and biomarker in various diseases. This article aims to explore the current understanding of LOC100128398 and its implications in the field of medicine.

What is LOC100128398?

LOC100128398, which stands for Long Intergenic Non-Protein Coding RNA 100128398, is an RNA molecule. It is a long non-coding RNA (lncRNA), a type of RNA that is not translated into protein. Instead, lncRNAs are involved in various cellular processes, including gene regulation and protein synthesis.

Expression of LOC100128398

LOC100128398 is expressed in a tissue-specific manner, meaning it is only present in certain tissues or organs in the human body. Various studies have shown differential expression of LOC100128398 in different diseases, suggesting its potential as a biomarker.

LOC100128398 as a Biomarker

One of the most exciting aspects of LOC100128398 is its potential as a biomarker. Biomarkers are measurable indicators that can provide information about the presence or progression of a disease. In recent years, researchers have identified several disease-specific signatures associated with LOC100128398 expression.

1. Cancer Biomarker: Several studies have shown that LOC100128398 is dysregulated in various cancers, including breast, lung, and colorectal cancers. Increased expression of LOC100128398 has been correlated with increased tumor size, metastasis, and poor prognosis. Therefore, LOC100128398 has the potential to serve as a diagnostic or prognostic biomarker in cancer patients.

2. Cardiovascular Biomarker: Studies have also revealed the role of LOC100128398 in cardiovascular diseases. It has been found to be upregulated in atherosclerotic plaques, suggesting its involvement in the progression of atherosclerosis. As a result, LOC100128398 could be a valuable biomarker for early detection and risk stratification in cardiovascular disease patients.

3. Neurological Biomarker: Emerging evidence suggests the potential of LOC100128398 as a biomarker for neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. Altered expression of LOC100128398 has been observed in brain tissues of patients with these conditions, indicating its potential as a diagnostic tool.

LOC100128398 as a Drug Target

In addition to its potential as a biomarker, LOC100128398 has also been explored as a drug target in certain diseases. The dysregulation of LOC100128398 in various pathological conditions makes it an attractive target for therapeutic interventions.

1. Cancer Therapy: Targeting LOC100128398 with specific inhibitors or modulators could potentially hinder tumor growth and metastasis. Researchers are investigating the potential of using antisense oligonucleotides and small interfering RNAs (siRNAs) to inhibit LOC100128398 expression, which could pave the way for novel cancer therapies.

2. Cardiovascular Interventions: Controlling the expression or activity of LOC100128398 could have therapeutic implications for cardiovascular diseases. It could potentially modulate atherosclerotic plaque formation and stabilize vulnerable plaques, thereby reducing the risk of cardiovascular events.

3. Neurodegenerative Disorders: Manipulating LOC100128398 expression could hold promise for treating neurodegenerative diseases. It may help regulate the underlying molecular mechanisms associated with conditions like Alzheimer's and Parkinson's disease.


LOC100128398, a long non-coding RNA, has emerged as an interesting target for both diagnostic and therapeutic purposes. Its tissue-specific expression and dysregulation in various diseases make it an attractive biomarker candidate. Additionally, the ability to manipulate its expression opens up exciting avenues for potential therapeutic interventions. Further research and clinical studies are needed to fully understand the role of LOC100128398 in different diseases and unlock its true potential in personalized medicine.

Protein Name: Uncharacterized LOC100128398

The "LOC100128398 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LOC100128398 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at

More Common Targets

LOC100128494 | LOC100128593 | LOC100128770 | LOC100128966 | LOC100128988 | LOC100129034 | LOC100129098 | LOC100129148 | LOC100129175 | LOC100129203 | LOC100129215 | LOC100129316 | LOC100129381 | LOC100129434 | LOC100129455 | LOC100129534 | LOC100129603 | LOC100129697 | LOC100130000 | LOC100130207 | LOC100130285 | LOC100130298 | LOC100130331 | LOC100130452 | LOC100130463 | LOC100130548 | LOC100130587 | LOC100130691 | LOC100130698 | LOC100130744 | LOC100130748 | LOC100130872 | LOC100130899 | LOC100130938 | LOC100130987 | LOC100130992 | LOC100131096 | LOC100131107 | LOC100131257 | LOC100131289 | LOC100131372 | LOC100131496 | LOC100131532 | LOC100131626 | LOC100131635 | LOC100131859 | LOC100131877 | LOC100131943 | LOC100132004 | LOC100132062 | LOC100132077 | LOC100132078 | LOC100132249 | LOC100132287 | LOC100132356 | LOC100132609 | LOC100132626 | LOC100132651 | LOC100132686 | LOC100132741 | LOC100132781 | LOC100132797 | LOC100133077 | LOC100133165 | LOC100133177 | LOC100133284 | LOC100133331 | LOC100133920 | LOC100134317 | LOC100134368 | LOC100134391 | LOC100134868 | LOC100190986 | LOC100233156 | LOC100240728 | LOC100240734 | LOC100240735 | LOC100271840 | LOC100272216 | LOC100272217 | LOC100286922 | LOC100287036 | LOC100287290 | LOC100287329 | LOC100287413 | LOC100287792 | LOC100287834 | LOC100287846 | LOC100287944 | LOC100288069 | LOC100288162 | LOC100288208 | LOC100288637 | LOC100288656 | LOC100289230 | LOC100289283 | LOC100289308 | LOC100289333 | LOC100289361 | LOC100289470