LINC01446: A GPCR Receptor and Potential Drug Target (G401337)

Target Name: LINC01446

NCBI ID: G401337

LINC01446

Other Name(s): GS1-179L18.1 | Long intergenic non-protein coding RNA 1446 | long intergenic non-protein coding RNA 1446

LINC01446: A GPCR Receptor and Potential Drug Target

LINC01446 (GS1-179L18.1) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the G-protein-coupled receptor (GPCR) family, which is a large superfamily of transmembrane proteins that play a key role in cellular signaling.

Members of the GPCR family usually consist of an 伪-helix, a 尾-sheet, and a 纬-chain. Alpha helices and beta sheets are helices connected by two beta hydrogen bonds, while gamma strands are helices connected by three beta hydrogen bonds. Receptors of the GPCR family usually bind to ligands and then trigger signal transduction pathways through phosphorylation of tyrosine residues.

LINC01446 plays an important role in various physiological processes. In the nervous system, LINC01446 plays a role in regulating the excitability and calming states of neurons. Research shows that LINC01446 interacts with glutamate receptors (GR) to jointly regulate neuronal excitability and synaptic transmission.

In the cardiovascular system, LINC01446 is involved in regulating the contraction and relaxation of cardiomyocytes. Research shows that LINC01446 interacts with 尾-adrenergic receptors (尾-AR) to jointly regulate the contraction and relaxation of cardiomyocytes.

In the kidney, LINC01446 is involved in regulating tubular sodium reabsorption. Studies have shown that LINC01446 interacts with sodium channels to jointly regulate the reabsorption of sodium ions by the renal tubules.

In addition, LINC01446 also interacts with a variety of other molecules, including insulin, thyroid hormones, and cytokines. These interactions enable LINC01446 to exert important biological functions in physiological processes.

Because LINC01446 plays an important role in a variety of physiological processes, it is considered a potential drug target. Many studies have explored the potential of LINC01446 as a drug target and discovered a variety of molecules that interact with LINC01446. These molecules include GR, 尾-AR, sodium channels, and insulin.

In addition, some studies have also explored the relationship between LINC01446 and disease. For example, studies have shown that LINC01446 is abnormally expressed in neurological diseases such as Alzheimer's disease and Parkinson's disease, and therefore may be related to the occurrence and progression of these diseases.

To sum up, LINC01446 is a protein that plays an important role in the nervous system, cardiovascular system and kidneys. By interacting with a variety of molecules, LINC01446 plays important biological functions in physiological processes. At the same time, LINC01446 is also considered a potential drug target that can be used to treat a variety of neurological and cardiovascular diseases.

Protein Name: Long Intergenic Non-protein Coding RNA 1446

The "LINC01446 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LINC01446 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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