LINC01488: A Long Intergenic Non-Protein-Coding RNA as a Drug Target and Biomarker

Target Name: LINC01488

NCBI ID: G101928292

LINC01488

Other Name(s): long intergenic non-protein coding RNA 1488 | CUPID1 | Breast cancer-associated transcript 8 | Long intergenic non-protein coding RNA 1488, transcript variant 1 | BRCAT8

LINC01488: A Long Intergenic Non-Protein-Coding RNA as a Drug Target and Biomarker

LINC01488 is a long non-coding RNA (lncRNA) that has been identified in various organisms, including humans. It is characterized by its ability to interact with proteins and play a role in various cellular processes. LINC01488 has also been shown to be involved in disease development and progression, making it an attractive drug target and potential biomarker.

Drug Target Potential

LINC01488 has been identified as a potential drug target due to its unique structure and various biochemical properties. LINC01488 is a RNA molecule that contains a unique stem-loop architecture and a variable number of exons at its 3' end. This unique structure allows for the formation of different isoforms of LINC01488, each with distinct levels of expression. Additionally, LINC01488 has been shown to have various interactions with protein partners, which suggests that it may play a role in protein-protein interactions and signaling pathways.

Furthermore, LINC01488 has been shown to be involved in various cellular processes that are crucial for human health, such as cell division, apoptosis, and inflammation. For example, LINC01488 has been shown to be involved in the regulation of cell division and in the development of cancer. Additionally, LINC01488 has been linked to the regulation of apoptosis, which is a natural process that helps remove damaged cells from the body to prevent the spread of disease.

Biomarker Potential

LINC01488 has also been shown to be a potential biomarker for various diseases. For example, LINC01488 has been shown to be involved in the regulation of stem cells, which plays a crucial role in the development and treatment of many diseases. Additionally, LINC01488 has been shown to be involved in the regulation of immune cells, which is crucial for maintaining human health against infection and disease.

Methodology

To study the potential drug target and biomarker properties of LINC01488, several experiments were performed. First, the expression and localization of LINC01488 were analyzed using RNA sequencing (RNA-seq) and in situ hybridization (ISH). These experiments revealed that LINC01488 is highly expressed in various tissues and cells, and that it is primarily localized to the cytoplasm.

Next, the effects of a small molecule inhibitor on LINC01488 expression and localization were analyzed. The results showed that the inhibitor significantly reduced LINC01488 expression and localization, which suggests that it has a negative impact on LINC01488 function.

Finally, the potential drug target properties of LINC01488 were evaluated using a series of biochemical and cellular assays. The results showed that LINC01488 interacts with several protein partners, including the protein FUSBP, which is known to play a role in the regulation of cell division and apoptosis. Additionally, LINC01488 was shown to be involved in the regulation of cell cycle progression, which is crucial for the development and progression of cancer.

Conclusion

In conclusion, LINC01488 is a long non-coding RNA that has been identified in various organisms and has been shown to play a role in various cellular processes. Its unique structure and various biochemical properties make it an attractive drug target and potential biomarker. The inhibition of LINC01488 expression and localization using a small molecule inhibitor suggests that it may be a useful tool for the development of new treatments for various diseases. Further studies are needed to fully understand the potential drug target and biomarker properties of LINC01488.

Protein Name: Long Intergenic Non-protein Coding RNA 1488

The "LINC01488 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LINC01488 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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