Target Name: SNORD116-1
NCBI ID: G100033413
Review Report on SNORD116-1 Target / Biomarker Content of Review Report on SNORD116-1 Target / Biomarker
Other Name(s): HBII-85-1 | Small nucleolar RNA, C/D box 116-1 | PWCR1 | small nucleolar RNA, C/D box 116-1

Understanding SNORD116-1: A Potential Disease Drug Target or Biomarker

SNORD116-1 has emerged as a potentially significant molecule in the field of biomedical research. This small nucleolar RNA (snoRNA) is found in humans and mainly expressed in the brain. Scientists have recently been exploring the possibility of utilizing SNORD116-1 as a disease drug target or biomarker due to its involvement in various neurological disorders. In this article, we delve into the intricacies of SNORD116-1 to shed light on its potential applications in healthcare.

The Significance of SNORD116-1

SNORD116-1 has gained attention due to its link to a specific genetic region associated with Prader-Willi syndrome (PWS). PWS is a complex genetic disorder characterized by a wide range of symptoms, including developmental delays, learning difficulties, obesity, and behavioral issues. Individuals with PWS often exhibit an abnormality in chromosome 15, resulting in the loss of genes within this region, including SNORD116-1.

SNOs and Their Role in Gene Expression

Small nucleolar RNAs (snoRNAs) are a diverse group of RNA molecules that localize primarily within the nucleolus of cells. They function as essential regulators of gene expression, with their main role being the modification and processing of other RNA molecules, such as ribosomal RNA (rRNA), transfer RNA (tRNA), and messenger RNA (mRNA). SnoRNAs achieve these tasks by guiding specific protein complexes to target RNA molecules, mediating the chemical modifications necessary for proper gene regulation.

The Relationship between SNORD116-1 and Prader-Willi Syndrome

Research has suggested a critical association between SNORD116-1 and Prader-Willi syndrome. The majority of individuals with PWS have a deletion of the paternal chromosome 15 region that includes SNORD116-1 and other snoRNAs. Multiple studies using mouse models have demonstrated that the loss of SNORD116-1 leads to various PWS-like symptoms, reinforcing its importance in the development of the disorder.

Potential Use as a Disease Drug Target

The identification of SNORD116-1 as a potential drug target offers new avenues for therapeutic interventions in PWS and related disorders. By targeting SNORD116-1-related mechanisms, scientists hope to develop treatments that can alleviate symptoms or potentially reverse the underlying genetic abnormalities. Various research initiatives are actively investigating the feasibility of developing drugs that modulate the expression or function of SNORD116-1, providing hope for individuals with PWS and their families.

Advances in Therapeutic Approaches

Understanding the complex molecular mechanisms involving SNORD116-1 has paved the way for innovative therapeutic approaches. Recent studies have shown promise in gene replacement therapy, aiming to reintroduce the missing SNORD116-1 genes into affected cells. Animal models have demonstrated improved symptomatology and physiological restoration through this approach, but further validation and clinical trials are necessary before its application in humans.

Potential Applications as a Biomarker

Apart from being a potential drug target, SNORD116-1 also shows promise as a biomarker in various neurological disorders. Biomarkers are measurable indicators that provide valuable insights into the progression, diagnosis, and treatment response of a particular disease. SNORD116-1 exhibits dysregulation in neurological conditions beyond PWS, including some forms of autism spectrum disorder and schizophrenia. Further research into its diagnostic potential may lead to the development of personalized medicine or early detection strategies.

The Future of SNORD116-1 Research

As research on SNORD116-1 continues to expand, several key areas require further investigation. Firstly, gaining a deeper understanding of the precise molecular mechanisms involving SNORD116-1 and its partnership with other molecules will be crucial for targeted therapeutic approaches. Additionally, exploration of SNORD116-1's potential as a biomarker in a broader range of neurological disorders may enable earlier diagnoses and personalized treatment strategies.


SNORD116-1 has emerged as a fascinating molecule with immense potential as a disease drug target or biomarker. Its intricate involvement in neurological disorders, particularly Prader-Willi syndrome, provides scientists with new avenues for therapeutic interventions. The ongoing advancements in understanding SNORD116-1's molecular mechanisms and exploring its diagnostic potential reflect promising prospects for improving the lives of individuals affected by these challenging conditions. Continued research and development in this field hold the key to unlocking innovative treatment strategies and personalized medicine in the future.

Protein Name: Small Nucleolar RNA, C/D Box 116-1

The "SNORD116-1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SNORD116-1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at

More Common Targets

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