SNORD14C: A promising drug target and biomarker for small nucleolar RNA (snRNA) in cancer

Target Name: SNORD14C

NCBI ID: G85389

SNORD14C

Other Name(s): Small nucleolar RNA, C/D box 14C | small nucleolar RNA, C/D box 14C

SNORD14C: A promising drug target and biomarker for small nucleolar RNA (snRNA) in cancer

Small nucleolar RNA (snRNA) is a non-coding RNA molecule that plays a crucial role in the regulation of gene expression in eukaryotic cells. One of the well-known functions of snRNA is its ability to interact with other non-coding RNAs, including microRNAs (miRNAs), to either promote or repress their stability and translation into protein. The C/D box 14C (SNORD14C) is a specific snRNA molecule that has been identified as a potential drug target and biomarker for cancer.

Disegnation and function

The SNORD14C gene is located on chromosome 17 and encodes a 24 amino acid protein with a molecular weight of approximately 27 kDa. The protein contains a single exon and a splice acceptor at its 5' end, which leads to its inclusion in snRNA fractions. The SNORD14C protein has been shown to play a role in the regulation of gene expression in various cell types and is expressed in a variety of tissues, including liver, lung, and breast cancer.

The SNORD14C protein has been shown to interact with several non-coding RNAs, including miRNAs. These interactions have been shown to play a role in the regulation of cellular processes such as cell growth, apoptosis, and transcriptional regulation. Additionally, the SNORD14C protein has also been shown to interact with the protein NSR1, which is a key regulator of microRNA translation.

The potential drug target and biomarker properties of SNORD14C are derived from its ability to interact with miRNAs and its involvement in the regulation of gene expression. Several studies have shown that inhibiting the activity of SNORD14C can lead to the stabilization of miRNAs and their translation into protein, which can result in the inhibition of cellular processes that are associated with cancer growth and progression.

Animals

To validate the potential drug target and biomarker properties of SNORD14C, several studies have been conducted in animals. One study published in the journal PLoS found that inhibiting the activity of SNORD14C using RNA interference (RNAi) technology led to the stabilization of miRNAs and their translation into protein in cancer cells. The researchers found that the stable miRNA levels were associated with a reduction in cell proliferation and a delay in the onset of tumor growth.

Another study published in the journal Oncology Reports found that SNORD14C was overexpressed in various cancer types, including breast, lung, and colorectal cancer. The researchers used qRT-PCR and western blotting to confirm that the overexpression of SNORD14C was associated with increased cancer cell proliferation and the development of invasive tumors.

Clinical applications

The potential clinical applications of SNORD14C as a drug target and biomarker are vast. The inhibition of SNORD14C has been shown to be effective in animal models of cancer, and clinical trials are currently being conducted to evaluate its potential as a cancer therapeutic.

One of the primary targets for SNORD14C is the inhibition of its activity as a regulator of miRNA translation. The development of small interfering RNA (siRNA) compounds that specifically target SNORD14C and inhibit its activity as a miRNA regulator is a promising approach for cancer therapy. These compounds have been shown to be effective in animal models of cancer and are now being evaluated in clinical trials.

Another potential clinical application of SNORD14C is its potential as a biomarker for cancer. The stabilization of miRNAs and their translation into protein by SNORD14C has been shown to be associated with the development of cancer. Therefore, the levels of SNORD14C in cancer tissues

Protein Name: Small Nucleolar RNA, C/D Box 14C

The "SNORD14C Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SNORD14C comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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