ABCB11 Related Diseases

ABCB11

Related Diseases

1) Primary Biliary Cholangitis
Primary Biliary Cholangitis, also known as primary biliary cirrhosis, is related to gastrointestinal system disease and non-alcoholic fatty liver disease. An important gene associated with Primary Biliary Cholangitis is PBC2 (Biliary Cirrhosis, Primary, 2), and among its related pathways/superpathways are miRNAs involved in DNA damage response and Cell differentiation - expanded index. The drugs Abatacept and Meropenem have been mentioned in the context of this disorder. Affiliated tissues include Umbilical Cord, liver and bone, and related phenotypes are cirrhosis and biliary cirrhosis

2) Sezary Syndrome
Sezary's Disease, also known as sezary syndrome, is related to primary cutaneous t-cell non-hodgkin lymphoma and lymphoma, hodgkin, classic, and has symptoms including pruritus An important gene associated with Sezary's Disease is BCL10 (BCL10 Immune Signaling Adaptor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Denileukin diftitox and Fosaprepitant have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and bone marrow, and related phenotypes are dry skin and neoplasm of the skin

3) Hepatitis C, Chronic
Hepatitis C, also known as hepatitis c infection, is related to hepatitis c virus and viral infectious disease, and has symptoms including fever, fatigue and loss of appetite. An important gene associated with Hepatitis C is MIR122 (MicroRNA 122), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Ezetimibe and Acarbose have been mentioned in the context of this disorder. Affiliated tissues include Blood, liver and kidney, and related phenotypes are Increased JFH-1 genotype 2a Hepatitis C virus (HCV) infection and immune system

4) Chronic Kidney Disease
Chronic Kidney Disease, also known as chronic renal disease, is related to kidney disease and end stage renal disease, and has symptoms including cloudy (hemodialysis) (peritoneal) dialysis effluent An important gene associated with Chronic Kidney Disease is COL4A4 (Collagen Type IV Alpha 4 Chain), and among its related pathways/superpathways are Signal Transduction and Primary focal segmental glomerulosclerosis (FSGS). The drugs Chlorhexidine and Fosinopril have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are homeostasis/metabolism and renal/urinary system

5) Hypothyroidism
Hypothyroidism, also known as thyroid diseases, is related to congenital hypothyroidism and hypothyroidism, congenital, nongoitrous, 1. An important gene associated with Hypothyroidism is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Thyroid stimulating hormone (TSH) signaling pathway and Thyroid hormones production and peripheral downstream signaling effects. The drugs Nitroprusside and Nitric Oxide have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and lymph node, and related phenotypes are Resistant to vaccinia virus (VACV-A4L) infection and homeostasis/metabolism

6) Cancer, Lung
Lung Cancer, also known as non-small cell lung carcinoma, is related to lung cancer susceptibility 3 and small cell cancer of the lung, and has symptoms including cough, chest discomfort and weight loss. An important gene associated with Lung Cancer is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are Innate Immune System and Apoptotic Pathways in Synovial Fibroblasts. The drugs Pemetrexed and Erlotinib have been mentioned in the context of this disorder. Affiliated tissues include lung, lungs and brain, and related phenotypes are lung adenocarcinoma and alveolar cell carcinoma

7) Sclerosing Cholangitis
Cholangitis, Primary Sclerosing, also known as primary sclerosing cholangitis, is related to portal hypertension and autoimmune pancreatitis, and has symptoms including icterus An important gene associated with Cholangitis, Primary Sclerosing is SEMA4D (Semaphorin 4D), and among its related pathways/superpathways is Defensins. The drugs Vancomycin and Bezafibrate have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and thyroid, and related phenotypes are autoimmunity and portal hypertension

8) Glioma
Glial Tumor, also known as glioma, is related to optic nerve glioma and brain stem glioma. The drugs Trametinib and Dabrafenib have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and bone marrow.

9) Cholestasis, Intrahepatic
Intrahepatic Cholestasis, also known as cholestasis, intrahepatic, is related to cholestasis, intrahepatic, of pregnancy 3 and cholestasis, progressive familial intrahepatic, 2, and has symptoms including icterus, hepatocellular jaundice and pruritus of pregnancy. An important gene associated with Intrahepatic Cholestasis is ABCB11 (ATP Binding Cassette Subfamily B Member 11), and among its related pathways/superpathways are Metabolism and Nuclear receptors meta-pathway. The drugs Sorbitol and Tocopherol have been mentioned in the context of this disorder. Affiliated tissues include liver, placenta and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

10) Hepatitis
Hepatitis, also known as chronic persistent hepatitis, is related to hepatitis c and hepatitis a, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Hepatitis is HAVCR1 (Hepatitis A Virus Cellular Receptor 1), and among its related pathways/superpathways are Toll-like receptor signaling pathway and Ebola virus infection in host. The drugs Glycyrrhizic acid and Acarbose have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and t cells, and related phenotypes are no effect and no effect

11) Cirrhosis
Liver Cirrhosis, also known as cirrhosis, is related to alcoholic liver cirrhosis and primary biliary cholangitis, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Liver Cirrhosis is FARSB (Phenylalanyl-TRNA Synthetase Subunit Beta), and among its related pathways/superpathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Lung fibrosis. The drugs Racivir and Propofol have been mentioned in the context of this disorder. Affiliated tissues include Bone and Blood.

12) Liver Diseases
Liver Disease, also known as liver diseases, is related to non-alcoholic fatty liver disease and fatty liver disease, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Liver Disease is MEG3 (Maternally Expressed 3), and among its related pathways/superpathways are Metabolism and Nuclear receptors meta-pathway. The drugs Perindopril and Amlodipine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and kidney, and related phenotypes are Reduced mammosphere formation and liver/biliary system

13) Gastrointestinal Disorders
Gastrointestinal System Disease, also known as gastrointestinal disease, is related to crohn's disease and stomach disease, and has symptoms including peeling tongue, catarrh and blood in stool. An important gene associated with Gastrointestinal System Disease is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are Cell differentiation - expanded index and miRNAs involved in DNA damage response. The drugs Indomethacin and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include gastrointestinal tract, small intestine and liver.

14) Cholestasis
Cholestasis, also known as obstruction of bile duct, is related to cholestasis, intrahepatic, of pregnancy 3 and cholestasis, benign recurrent intrahepatic, 2, and has symptoms including icterus and jaundice (not of newborn). An important gene associated with Cholestasis is USP53 (Ubiquitin Specific Peptidase 53), and among its related pathways/superpathways are Metabolism and Nuclear receptors meta-pathway. The drugs Lactulose and Sorbitol have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and kidney, and related phenotypes are no effect and no effect

15) Cholelithiasis
Cholelithiasis is related to somatostatinoma and gallbladder disease 4. An important gene associated with Cholelithiasis is ABCB4 (ATP Binding Cassette Subfamily B Member 4), and among its related pathways/superpathways are Metabolism and Metabolism of steroids. The drugs Ketamine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and colon, and related phenotypes are no effect and no effect

16) Autism Spectrum Disorders
Autism Spectrum Disorder, also known as autism spectrum disorders, is related to autism and attention deficit-hyperactivity disorder, and has symptoms including widespread abnormalities of social interactions, severely restricted interests and highly repetitive behavior. An important gene associated with Autism Spectrum Disorder is SHANK2 (SH3 And Multiple Ankyrin Repeat Domains 2), and among its related pathways/superpathways are Thyroid hormones production and peripheral downstream signaling effects and Rett syndrome causing genes. The drugs Acetylcholine and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and prefrontal cortex, and related phenotypes are nervous system and growth/size/body region

17) Benign Recurrent Intrahepatic Cholestasis 1
Cholestasis, Benign Recurrent Intrahepatic, 1, also known as benign recurrent intrahepatic cholestasis, is related to cholestasis, benign recurrent intrahepatic, 2 and cholestasis, progressive familial intrahepatic, 2, and has symptoms including diarrhea, icterus and pruritus. An important gene associated with Cholestasis, Benign Recurrent Intrahepatic, 1 is ATP8B1 (ATPase Phospholipid Transporting 8B1), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. Affiliated tissues include liver, pancreas and skin, and related phenotypes are fatigue and elevated hepatic transaminase

18) Progressive Familial Intrahepatic Cholestasis
Cholestasis, Progressive Familial Intrahepatic, 1, also known as byler disease, is related to cholestasis, progressive familial intrahepatic, 3 and cholestasis, progressive familial intrahepatic, 4, and has symptoms including diarrhea, icterus and pruritus. An important gene associated with Cholestasis, Progressive Familial Intrahepatic, 1 is ATP8B1 (ATPase Phospholipid Transporting 8B1), and among its related pathways/superpathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Cardiac conduction. The drugs Bile Acids and Salts and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include liver, appendix and lung, and related phenotypes are osteopenia and hepatomegaly

19) Progressive Familial Intrahepatic Cholestasis Type 1
Cholestasis, Progressive Familial Intrahepatic, 1, also known as byler disease, is related to cholestasis, progressive familial intrahepatic, 3 and cholestasis, progressive familial intrahepatic, 4, and has symptoms including diarrhea, icterus and pruritus. An important gene associated with Cholestasis, Progressive Familial Intrahepatic, 1 is ATP8B1 (ATPase Phospholipid Transporting 8B1), and among its related pathways/superpathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Cardiac conduction. The drugs Bile Acids and Salts and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include liver, appendix and lung, and related phenotypes are osteopenia and hepatomegaly

20) Progressive Familial Intrahepatic Cholestasis Type 2
Cholestasis, Progressive Familial Intrahepatic, 2, also known as pfic2, is related to familial intrahepatic cholestasis and atp8b1 deficiency, and has symptoms including diarrhea, icterus and pruritus. An important gene associated with Cholestasis, Progressive Familial Intrahepatic, 2 is ABCB11 (ATP Binding Cassette Subfamily B Member 11), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. The drug Bile Acids and Salts has been mentioned in the context of this disorder. Affiliated tissues include liver and spleen, and related phenotypes are failure to thrive and splenomegaly

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