ABCD3: A Promising Drug Target and Biomarker for Peroxisomal Membrane Protein

Target Name: ABCD3

NCBI ID: G5825

ABCD3

ABCD3: A Promising Drug Target and Biomarker for Peroxisomal Membrane Protein

Abstract: Peroxisomes are organelles that are involved in the detoxification of harmful substances in the body. They are highly conserved and play a crucial role in maintaining cellular homeostasis. One of the peroxisomal membrane proteins, ABCD3, has been identified as a potential drug target and biomarker. This article will provide an overview of ABCD3, its function in peroxisomes, its potential as a drug target, and its role as a biomarker for various diseases.

Introduction:

Peroxisomes are organelles that are involved in the detoxification of harmful substances in the body. They are highly conserved and play a crucial role in maintaining cellular homeostasis. Peroxisomes are composed of a perimembrane protein, which is the protein that surrounds the peroxisome, and a cytoplasmic protein that is located inside the peroxisome. The perimembrane protein is the main structural component of the peroxisome and is involved in its stability and integrity.

ABCD3: A Peroxisomal Membrane Protein

ABCD3 is a peroxisomal membrane protein that is expressed in various tissues and organs. It is one of the largest peroxisomal membrane proteins, with a molecular weight of approximately 160 kDa. ABCD3 is composed of four transmembrane domains and a cytoplasmic tail. The transmembrane domains are involved in the formation of the peroxisomal pore, which is the channel through which the peroxisome secretes its contents.

Function:

ABCD3 is involved in various cellular processes, including the detoxification of xenobiotics and the regulation of cellular signaling pathways. One of its functions is to regulate the detoxification of xenobiotics by the peroxisome. Xenobiotics, such as toxins and drugs, can damage peroxisomes and disrupt their function. ABCD3 helps to maintain the stability and integrity of the peroxisome, allowing it to function properly and protect the cell from damage.

Drug Target:

ABCD3 has been identified as a potential drug target for various diseases. Its high stability and importance in cellular processes make it an attractive target for small molecules that can modulate its function. Several studies have shown that inhibitors of ABCD3 can cause a decrease in the formation of peroxisomes, leading to increased levels of toxic substances in the cell. This suggests that ABCD3 may be a useful biomarker for diseases where peroxisomal dysfunction is involved.

Biomarker:

ABCD3 has also been identified as a potential biomarker for various diseases. Its expression and function are regulated by various cellular signaling pathways, including TGF-β and NF-kappa-B signaling pathways. Several studies have shown that changes in the expression and function of ABCD3 can be used as biomarkers for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Conclusion:

In conclusion, ABCD3 is a peroxisomal membrane protein that is involved in various cellular processes and has been identified as a potential drug target and biomarker for various diseases. Its high stability and importance in cellular processes make it an attractive target for small molecules that can modulate its function. Further research is needed to fully understand its role in peroxisomes and its potential as a drug target and biomarker for various diseases.

Protein Name: ATP Binding Cassette Subfamily D Member 3

Functions: Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation (PubMed:11248239, PubMed:25168382, PubMed:24333844, PubMed:29397936). Has fatty acyl-CoA thioesterase and ATPase activities (PubMed:29397936). Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes (By similarity). Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:25944712, PubMed:24333844)

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