Target Name: SNORD116-16
NCBI ID: G100033428
Review Report on SNORD116-16 Target / Biomarker Content of Review Report on SNORD116-16 Target / Biomarker
Other Name(s): small nucleolar RNA, C/D box 116-16 | HBII-85-16 | Small nucleolar RNA, C/D box 116-16

What is SNORD116-16?

SNORD116-16 is a small nucleolar RNA (snoRNA) located in the Prader-Willi Syndrome (PWS) region on chromosome 15. SnoRNAs are a class of non-coding RNA molecules that primarily function in the modification and processing of other RNA molecules. SNORD116-16, specifically, has been linked to the development and progression of various diseases and has emerged as a potential drug target and biomarker. In this article, we will explore the significance of SNORD116-16 in disease research and its potential implications in therapeutic interventions.

The Role of SNORD116-16 in Disease

Research has shown that SNORD116-16 plays a crucial role in the regulation of gene expression and various cellular processes. It has been extensively studied in the context of Prader-Willi Syndrome, a complex genetic disorder characterized by intellectual disabilities, behavioral problems, and a constant sense of hunger leading to obesity. Individuals with PWS typically have a deletion, mutation, or epigenetic silencing of genes in the PWS region, including SNORD116-16.

Recent studies have suggested that the absence or dysfunction of SNORD116-16 contributes to the pathophysiology of PWS. It has been observed that SNORD116-16 is critical for the correct processing and maturation of specific proteins involved in appetite regulation, energy balance, and hypothalamic function. Dysregulation of these processes due to SNORD116-16 deficiency contributes to the characteristic clinical features of PWS, such as insatiable hunger and obesity.

SNORD116-16 as a Disease Drug Target

The unique role of SNORD116-16 in various disease processes makes it a promising target for therapeutic interventions. Researchers are actively investigating ways to restore SNORD116-16 expression or function in individuals with PWS. One potential approach includes the use of gene therapy to deliver functional copies of the SNORD116-16 gene into the cells of affected individuals. This could potentially correct the underlying genetic defect and improve the symptoms associated with PWS.

Additionally, scientists are exploring the use of small molecules or compounds that can modulate SNORD116-16 expression or activity. By targeting the molecular pathways involved in SNORD116-16 regulation, it may be possible to restore its function or compensate for its deficiency. These approaches hold great promise for developing novel therapeutic strategies for PWS and potentially other disorders in which SNORD116-16 plays a significant role.

SNORD116-16 as a Biomarker

In addition to its potential as a therapeutic target, SNORD116-16 has shown promise as a diagnostic biomarker for certain diseases. Several studies have demonstrated altered expression levels of SNORD116-16 in various cancers, including glioblastoma and breast cancer. Changes in SNORD116-16 expression have also been associated with neurodegenerative disorders, such as Parkinson's and Alzheimer's disease.

Monitoring SNORD116-16 expression levels could potentially serve as a non-invasive diagnostic tool for these diseases, allowing for early detection and intervention. Furthermore, SNORD116-16 expression could provide valuable insights into disease progression and prognosis. While further research is needed to validate SNORD116-16 as a reliable biomarker, its potential as a diagnostic tool holds significant promise for improving disease management and patient outcomes.

The Future of SNORD116-16 Research

As our understanding of the role of SNORD116-16 in disease expands, it is likely that further research will uncover additional therapeutic targets and applications. The development of targeted therapies aimed at restoring SNORD116-16 function could revolutionize the treatment options available for individuals with PWS and potentially other diseases.

Moreover, the discovery of SNORD116-16 as a potential biomarker opens up numerous possibilities for early diagnosis, personalized medicine, and monitoring the efficacy of treatments. By harnessing the power of snoRNAs like SNORD116-16, we have an opportunity to unlock new insights into disease processes and develop innovative strategies for patient care.


SNORD116-16, a snoRNA located in the Prader-Willi Syndrome region, has emerged as a significant player in disease research. Its role in regulating gene expression and cellular processes has implications for a range of diseases, making it an attractive drug target and potential biomarker. The development of therapeutic interventions and diagnostic tools based on SNORD116-16 could have profound implications for disease management and patient outcomes. As research in this field continues to advance, it is essential to explore the full potential of SNORD116-16 and expand our understanding of its role in various diseases.

Protein Name: Small Nucleolar RNA, C/D Box 116-16

The "SNORD116-16 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SNORD116-16 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at

More Common Targets

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