RPS15A: A Potential Drug Target and Biomarker for Cancer (G6210)

Target Name: RPS15A

NCBI ID: G6210

RPS15A

RPS15A: A Potential Drug Target and Biomarker for Cancer

RPS15A (DBA20) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the RhoA gene family, which is known for their role in cell signaling and cytoskeletal organization. RPS15A has been shown to play a role in the regulation of mitochondrial function and has been implicated in a number of cellular processes, including cell division, apoptosis, and inflammation.

Drug Targeting

RPS15A is a potential drug target due to its unique structure and the various functions it is involved in. One of the main reasons for its potential as a drug target is its cytoplasmic localization, which allows it to be easily targeted by small molecules. Additionally, its protein expression has been shown to be regulated by a number of different factors, including DNA methylation and histone modification, which can make it more responsive to therapeutic interventions.

Another potential mechanism by which RPS15A may be targeted is its role in the regulation of mitochondrial function. Mitochondria are important organelles that are responsible for generating energy for the cell through a process called cellular respiration. RPS15A has been shown to play a role in regulating the mitochondrial cytoskeleton, which is responsible for maintaining the structure and organization of the mitochondria. This is important because changes in the structure and function of the mitochondria can have a significant impact on cellular metabolism and energy production.

In addition to its role in mitochondrial function, RPS15A has also been shown to be involved in a number of signaling pathways that are important for cellular growth and development. For example, it has been shown to play a role in the regulation of the Wnt signaling pathway, which is involved in the regulation of cell growth and differentiation. Additionally, RPS15A has been shown to be involved in the regulation of the Notch signaling pathway, which is involved in the regulation of cell survival and proliferation.

Biomarker

RPS15A has also been shown to be a potential biomarker for a number of diseases, including cancer. For example, studies have shown that RPS15A is often expressed in various types of cancer, including breast, ovarian, and prostate cancer. This suggests that it may be a useful target for cancer therapies that target these tumors. Additionally, RPS15A has been shown to be involved in the regulation of cell division, which is a key aspect of cancer growth and progression. This suggests that it may be a useful target for therapies that aim to inhibit cell division in cancer cells.

Conclusion

RPS15A is a protein that has been shown to play a number of important roles in various cellular processes, including cell signaling and cytoskeletal organization. Its unique cytoplasmic localization and the various functions it is involved in make it a potential drug target. Additionally, its protein expression has been shown to be regulated by a number of different factors, including DNA methylation and histone modification, which can make it more responsive to therapeutic interventions. Furthermore, RPS15A has also been shown to be involved in the regulation of mitochondrial function and has been implicated in a number of signaling pathways that are important for cellular growth and development. Its potential as a biomarker for cancer makes it an attractive target for future therapeutic interventions.

Protein Name: Ribosomal Protein S15a

Functions: Component of the small ribosomal subunit (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Required for proper erythropoiesis (PubMed:27909223)

The "RPS15A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RPS15A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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