MIR645: A Potential Drug Target and Biomarker for Alzheimer's disease
MIR645: A Potential Drug Target and Biomarker for Alzheimer's disease
Introduction
Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions of people worldwide, leading to progressive memory loss, decline in cognitive abilities, and eventually, death. Currently, there is no cure for AD, and treatment options are limited to managing symptoms and improving quality of life. As the number of cases continues to rise, the development of new and effective therapies is crucial. MIR645, a microRNA (miRNA), has been identified as a potential drug target and biomarker for AD.
MIR645: A miRNA Target
MIR645 is a non-coding RNA molecule that has been identified in various organisms, including humans. It is composed of 29 amino acids and has a unique 3'-end covered with hydroxyl (-OH) and a 5'-end covered with phosphate group (-ORF). MIR645 has been shown to play a role in various cellular processes, including cell growth, survival, and reproduction [1, 2].
In recent years, researchers have become increasingly interested in MIR645 as a potential drug target for AD. Several studies have shown that MIR645 is downregulated in the brains of people with AD, and that it is involved in the development of neurodegeneration in these individuals [3 , 4].
MIR645 has also been shown to interact with several other miRNAs, including miR-202, miR-204, and miR-208. These interactions may have implications for the regulation of cellular processes and the development of neurodegeneration in AD [5, 6].
MIR645: A Biomarker
In addition to its potential as a drug target, MIR645 has also been identified as a potential biomarker for AD. The decreased expression of MIR645 in the brains of people with AD has been shown to be associated with the decline in cognitive abilities and memory that is typically observed in these individuals [7, 8].
MIR645 has also been shown to be involved in the regulation of cellular processes that are important for the development of neurodegeneration in AD. For example, MIR645 has been shown to be involved in the regulation of the translation of the proteinsynthase gene (PSG), which is responsible for the production of a protein involved in the formation of beta-amyloid plaques, a hallmark of AD [9, 10].
MIR645 has also been shown to be involved in the regulation of the neurotransmitter serotonin, which is involved in mood regulation and has been implicated in the development of AD [11, 12].
Conclusion
MIR645 is a microRNA that has been shown to play a role in various cellular processes and has been identified as a potential drug target and biomarker for AD. Its unique 3'-end is covered with hydroxyl group (-OH) and 5'-end is covered with The phosphate group (-ORF) structure, as well as its interaction with other miRNAs, makes it an attractive target for drug development. Further research is needed to fully understand the role of MIR645 in the development and treatment of AD.
Protein Name: MicroRNA 645
The "MIR645 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MIR645 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
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