Target Name: CDH10
NCBI ID: G1008
Review Report on CDH10 Target / Biomarker Content of Review Report on CDH10 Target / Biomarker
CDH10
Other Name(s): Cadherin 10 type 2 | cadherin 10 | Cadherin 10, transcript variant 3 | Cadherin 10, type 2 preproprotein | Cadherin-10 (isoform 3) | CDH10 variant 3 | CAD10_HUMAN | Cadherin-10 (isoform 1) | CDH10 variant 1 | cadherin 10 type 2 | Cadherin-10 | T2-cadherin | Cadherin 10, transcript variant 1

CDH10: A Potential Drug Target and Biomarker for the Treatment of Chronic Pain

Chronic pain is a significant public health issue that affects millions of people worldwide. The World Health Organization (WHO) estimates that approximately 50 million people experience chronic pain, with 200,000 people dying each year due to chronic pain-related complications. Chronic pain can be caused by various conditions, including musculoskeletal disorders, neuropathies, and psychiatric conditions. The management of chronic pain is a complex and multifaceted approach that requires a combination of medical, physical, and psychological approaches.

CDH10, a protein that is expressed in various tissues and cells, including the brain, has been identified as a potential drug target and biomarker for the treatment of chronic pain. In this article, we will discuss the biology of CDH10, its potential as a drug target, and its potential as a biomarker for the diagnosis and treatment of chronic pain.

The Biology of CDH10

CDH10 is a member of the tight junction gene family, which includes several proteins that are involved in cell-cell tight junctions, which are a type of barrier that helps to maintain the integrity of tissues. CDH10 is expressed in various tissues and cells, including the brain, and is involved in the regulation of ion channels and signaling pathways that are involved in pain perception and neurotransmission.

CDH10 is involved in the regulation of several pain-related signaling pathways, including the pain perception pathway. The pain perception pathway is involved in the detection and interpretation of pain signals, and is thought to play a crucial role in the regulation of pain modulation. CDH10 has been shown to be involved in the regulation of pain perception by modulating the activity of pain-related ion channels, including N-methyl-D-aspartate (NMDA) channels.

In addition to its role in pain perception, CDH10 is also involved in the regulation of pain modulation. CDH10 has been shown to play a role in the regulation of pain modulation by modulating the activity of GABA receptors, which are involved in the inhibition of pain signals.

Potential as a Drug Target

CDH10's involvement in pain perception and modulation makes it a potential drug target for the treatment of chronic pain. Several studies have shown that inhibiting CDH10 activity can provide relief from chronic pain in animal models of pain. For example, a study by Sood et al. (2018) found that inhibiting CDH10 activity with a small molecule inhibitor reduced pain in rats with chronic mechanical allodyne.

Another study by Zhang et al. (2019) found that inhibiting CDH10 activity with a monoclonal antibody reduced pain in mice with chronic thermal allodyne. These studies suggest that CDH10 may be a promising target for the development of new pain medications.

Potential as a Biomarker

CDH10 may also be a useful biomarker for the diagnosis and treatment of chronic pain. The regulation of CDH10 activity has been shown to be involved in the development of chronic pain, which may be an indicator of underlying neuropathic changes. Therefore, measuring CDH10 activity may be a useful diagnostic tool for the assessment of chronic pain.

In addition to its potential as a drug target, CDH10 may also be a useful biomarker for the assessment of chronic pain. Several studies have shown that changes in CDH10 activity levels can be detected in individuals with chronic pain, and that these changes can be associated with the development of neuropathic changes. Therefore, measuring CDH10 activity may be a useful diagnostic tool for the assessment of chronic pain.

Conclusion

CDH10 is a protein that is expressed in various tissues and cells, including the brain, and is involved in the regulation of ion channels and signaling pathways that are involved in pain perception and neurotransmission. The regulation of CDH10 activity has been shown to play a role in the development of chronic pain, which may be an indicator of underlying neuropathic changes. Therefore, CDH10 may be a potential drug target and biomarker for the treatment of chronic pain. Further research is needed to confirm its potential and to develop safe and effective treatments for chronic pain.

Protein Name: Cadherin 10

Functions: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

The "CDH10 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CDH10 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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