BUB3: A Potential Drug Target and Biomarker (G9184)

Target Name: BUB3

NCBI ID: G9184

BUB3

BUB3: A Potential Drug Target and Biomarker

Introduction

BUB3 (Budding Uninhibited by Benzimidazoles 3) is a non-coding RNA molecule that has been identified as a potential drug target and biomarker. It is a key regulator of cell growth and has been involved in various cellular processes, including cell adhesion, migration, and invasion. BUB3 is a highly conserved gene that is located on chromosome 18q and has been annotated as a potential regulator of the TGF-灏? pathway.

Drug Target Potential

BUB3 has been identified as a potential drug target due to its involvement in cell signaling pathways. It has been shown to play a role in regulating cell proliferation, migration, and invasion. BUB3 has also been shown to be involved in the regulation of cell adhesion, which is a critical process for the development and maintenance of tissues and organs.

In addition to its role in cell signaling pathways, BUB3 has also been shown to be involved in the regulation of cellular processes that are important for cancer progression. For example, BUB3 has been shown to promote the growth and survival of cancer cells . It has also been shown to contribute to the development and progression of various types of cancer, including neurobladder cancer, ovarian cancer, and colorectal cancer.

Biomarker Potential

BUB3 has also been identified as a potential biomarker for various types of cancer. For example, BUB3 has been shown to be expressed in various types of cancer, including breast, ovarian, and colorectal cancer. It has also been shown to be involved in the regulation of cellular processes that are important for cancer progression, such as cell adhesion and migration.

Expression and regulation

BUB3 is a highly conserved gene that is located on chromosome 18q. It has been shown to have a role in regulating cell growth and development, as well as in the regulation of cellular processes that are important for cancer progression. BUB3 has been shown to be involved in the regulation of cell adhesion, which is a critical process for the development and maintenance of tissues and organs.

BUB3 has also been shown to be involved in the regulation of cell migration, which is a critical process for the development of new tissues and organs. It has been shown to play a role in the regulation of cell proliferation, which is a critical process for the development and maintenance of tissues and organs.

In addition to its role in cell signaling pathways, BUB3 has also been shown to be involved in the regulation of cellular processes that are important for cancer progression. For example, BUB3 has been shown to promote the growth and survival of cancer cells . It has also been shown to contribute to the development and progression of various types of cancer, including neurobladder cancer, ovarian cancer, and colorectal cancer.

Conclusion

In conclusion, BUB3 is a non-coding RNA molecule that has been identified as a potential drug target and biomarker. It is a key regulator of cell growth and has been involved in various cellular processes, including cell adhesion, migration, and invasion. Its potential as a drug target is based on its involvement in cell signaling pathways and its role in the regulation of cancer progression. Further research is needed to fully understand the role of BUB3 as a drug target and biomarker.

Protein Name: BUB3 Mitotic Checkpoint Protein

Functions: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1

The "BUB3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about BUB3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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