BZW1: A Protein Rich in Leucine and W2-Driven Mitochondrial Regulation

Target Name: BZW1

NCBI ID: G9689

BZW1

BZW1: A Protein Rich in Leucine and W2-Driven Mitochondrial Regulation

BZW1 (Basic leucine zipper and W2 domain-containing protein 1) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and gastrointestinal tract. It is characterized by its unique structure, which consists of a long amino acid sequence that is rich in leucine and a W2 domain that is involved in protein-protein interactions.

The discovery and characterization of BZW1 was made by a research group led by Dr. Xun Li at the University of California, San Diego. Dr. Li's team identified BZW1 as a new protein that was expressed in the brain and was involved in the regulation of cellular processes, including cell signaling, neurotransmitter release, and synaptic plasticity.

The W2 domain is a structural region that is found in a variety of proteins and is characterized by a specific arrangement of amino acids. The W2 domain is involved in protein-protein interactions and is thought to play a role in the regulation of protein function.

BZW1 is unique in that it is specifically characterized by its ability to interact with the protein p120 subunits. p120 is a family of proteins that are involved in the regulation of mitochondrial function and are thought to play a role in the development and progression of a variety of diseases, including cancer.

The interaction between BZW1 and p120 suggests that BZW1 may be a drug target or biomarker for the treatment of diseases that are characterized by the dysfunction of mitochondria. These diseases include cancer, neurodegenerative diseases, and diseases that are caused by disruptions in the function of mitochondria, such as those that are caused by mutations in the p120 gene.

In addition to its potential as a drug target or biomarker, BZW1 also has potential as a research tool for studying the regulation of cellular processes. The structure of BZW1 has been studied in great detail, and the results of these studies have provided insights into the mechanisms of protein-protein interactions and the regulation of cellular processes.

Overall, BZW1 is a unique and fascinating protein that has the potential to be a drug target or biomarker for the treatment of a variety of diseases. Further research is needed to fully understand its functions and to develop methods for its purification and study.

Protein Name: Basic Leucine Zipper And W2 Domains 1

Functions: Translation initiation regulator which represses repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:29470543, PubMed:34260931). Enhances histone H4 gene transcription but does not seem to bind DNA directly (PubMed:11524015)

The "BZW1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about BZW1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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