ACTR3: A Promising Drug Target / Biomarker (G10096)

Target Name: ACTR3

NCBI ID: G10096

ACTR3

ACTR3: A Promising Drug Target / Biomarker

ACTR3 (Aspartic Acid Transporter 3) is a protein that is expressed in various tissues and cells throughout the body. It plays a crucial role in the regulation of aspartic acid, which is a crucial amino acid that is involved in various cellular processes. Aspartic acid is also known as spermidine, and it is found in high concentrations in the body's red blood cells. It is important for maintaining the proper structure and function of red blood cells, which are responsible for carrying oxygen from the lungs to the rest of the body.

ACTR3 is a member of the protein transporter family 1 (P-T family), which includes proteins that transport various molecules, including aspartic acid and other amino acids. These proteins help to ensure that these molecules reach their correct destinations and are involved in the regulation of cellular processes.

Disease and Research

Several studies have identified ACTR3 as a potential drug target or biomarker for various diseases. One of the main targets for ACTR3 is cancer, as it has been shown to be involved in the regulation of cellular processes that are often disrupted in cancer cells.

For example, studies have shown that high levels of ACTR3 are associated with poor prognosis in various types of cancer, including breast, ovarian, and prostate cancers. Additionally, ACTR3 has been shown to be involved in the regulation of cell division, which is a crucial process for cancer growth.

Another potential target for ACTR3 is neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Studies have shown that ACTR3 is involved in the regulation of the transport of various molecules to the brain, which may be involved in the development and progression of these diseases.

In addition to its potential therapeutic uses, ACTR3 has also been shown to be a useful biomarker for various diseases. For example, studies have shown that ACTR3 is involved in the regulation of aspartic acid levels in the brain, which may be a useful biomarker for Alzheimer's disease. Additionally, ACTR3 has been shown to be involved in the regulation of the transport of other molecules to the brain, which may be useful for the diagnosis and treatment of other neurodegenerative diseases.

Conclusion

In conclusion, ACTR3 is a protein that is involved in the regulation of aspartic acid in various tissues and cells throughout the body. Its role in cellular processes is crucial for maintaining the proper structure and function of red blood cells, which are responsible for carrying oxygen from the lungs to the rest of the body.

Several studies have identified ACTR3 as a potential drug target or biomarker for various diseases, including cancer and neurodegenerative diseases. Further research is needed to fully understand the role of ACTR3 in these processes and to develop effective treatments.

Protein Name: Actin Related Protein 3

Functions: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Plays a role in ciliogenesis (PubMed:20393563)

The "ACTR3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ACTR3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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