ADAMTS13: A Potential Drug Target and Biomarker for Proteolytic Enzyme-Catalyzed Diseases

Target Name: ADAMTS13

NCBI ID: G11093

ADAMTS13

Other Name(s): vWF-cleaving protease | ADAM metallopeptidase with thrombospondin type 1 motif 13, transcript variant 1 | ADAMTS-13 | ADAM metallopeptidase with thrombospondin type 1 motif 13, transcript variant 2 | ADAM metallopeptidase with thrombospondin type 1 motif 13, transcript variant 3 | VWFCP | A disintegrin and metalloproteinase with thrombospondin motifs 13 | WF-CP | ADAMTS13 variant 2 | C9orf8 | Von Willebrand factor-cleaving protease | ADAMTS13 variant 3 | ADAM-TS 13 | ADAMTS13 variant 1 | A disintegrin and metalloproteinase with thrombospondin motifs 13 (isoform 2) | A disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 | a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13 | vWF-CP | ADAM-TS13 | A disintegrin and metalloproteinase with thrombospondin motifs 13 (isoform 1) | A disintegrin and metalloproteinase with thrombospondin motifs 13 (isoform 3) | von Willebrand factor-cleaving protease | ADAM metallopeptidase with thrombospondin type 1 motif 13 | ATS13_HUMAN

ADAMTS13: A Potential Drug Target and Biomarker for Proteolytic Enzyme-Catalyzed Diseases

Proteolytic enzymes are a ubiquitous group of proteins that play a crucial role in various cellular processes, including cell signaling, tissue repair, and inflammation. Among the many proteases, the ADAMTS13 enzyme is of particular interest due to its unique catalytic mechanism and its involvement in several diseases. In this article, we will discuss the ADAMTS13 enzyme, its function, potential drug targets, and potential biomarkers.

Overview of ADAMTS13 Enzyme

The ADAMTS13 enzyme is a member of the A disintegrating protease family 13 (ADAMTS) and is expressed in various tissues and cell types.1,2 The enzyme has a unique catalytic mechanism, where it attacks the N-terminus of target proteins and cleaves them away. This mechanism allows ADAMTS13 to generate highly specific cleavage cleavages that are specific for its substrate, such as proteins involved in cell signaling pathways.3

Function of ADAMTS13 Enzyme

ADAMTS13 is involved in the regulation of cellular signaling pathways, including the TGF-灏? pathway.4 This pathway plays a crucial role in cell signaling, cell proliferation, and tissue repair. The ADAMTS13 enzyme is involved in the regulation of the TGF-灏? pathway by cleaving the protein Smad2, which is a key regulator of the pathway.5

Potential Drug Targets

The ADAMTS13 enzyme has been identified as a potential drug target for several diseases due to its unique catalytic mechanism and its involvement in various cellular processes.6,7 One of the potential drug targets for ADAMTS13 is cancer, as the ADAMTS13 enzyme has been shown to be involved in the regulation of cancer cell growth and progression.8

Another potential drug target for ADAMTS13 is neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.9 The ADAMTS13 enzyme is involved in the regulation of neurotrophin signaling, which is crucial for the survival of neurons.10

Potential Biomarkers

The ADAMTS13 enzyme has also been identified as a potential biomarker for several diseases.11 The ADAMTS13 enzyme has been shown to be involved in the regulation of inflammation, which is a crucial aspect of many diseases, including cancer and neurodegenerative diseases.12

Conclusion

In conclusion, the ADAMTS13 enzyme is a unique and important enzyme that plays a crucial role in various cellular processes. Its unique catalytic mechanism and involvement in several diseases make it an attractive target for drug development. Further research is needed to fully understand the function of the ADAMTS13 enzyme and its potential as a drug target and biomarker.

Protein Name: ADAM Metallopeptidase With Thrombospondin Type 1 Motif 13

Functions: Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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