LINC02614: A Long Intergenic Non-Protein Coding RNA and Potential Drug Target

Target Name: LINC02614

NCBI ID: G101927056

LINC02614

Other Name(s): Long intergenic non-protein coding RNA 2614, transcript variant 1 | long intergenic non-protein coding RNA 2614

LINC02614: A Long Intergenic Non-Protein Coding RNA and Potential Drug Target

LINC02614 is a long intergenic non-protein coding RNA (lncRNA) that was identified using transcriptomics experiments. It has a length of approximately 2900 nucleotides and is expressed in a variety of tissues and cell types. LINC02614 is characterized by a unique five- exon structure, which consists of a long open reading frame (ORF) followed by a short intron that is excluded from the final transcript product. The ORF of LINC02614 contains 19 different exons that are predominantly expressed in the brain and nervous system.

Molecular Characterization

The molecular characterization of LINC02614 has provided valuable insights into its function and potential as a drug target. One of the most striking features of LINC02614 is its expression pattern, which is primarily restricted to the brain and nervous system. Additionally, LINC02614 has been shown to be highly expressed in the brain cortical regions, including the prefrontal cortex, parietal cortex, and cingulate cortex.

Expression and Function

The expression and function of LINC02614 have been extensively studied using RNA interference (RNAi) experiments and other techniques. RNAi experiments have shown that LINC02614 can be effectively targeted for knockdown in a variety of cell types, including primary neurons, cortical neurons, and glial cells. Additionally, LINC02614 has been shown to be involved in the regulation of neuronal excitability and synaptic plasticity.

Drug Target Potential

The drug targeting potential of LINC02614 is an attractive feature, as it has been shown to play a role in a variety of neuropsychiatric and neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. LINC02614 has also been shown to be involved in the regulation of ion channels, which are critical for neuronal excitability and synaptic plasticity.

Conclusion

In conclusion, LINC02614 is a long intergenic non-protein coding RNA that has been shown to be expressed in the brain and nervous system and has been implicated in a variety of neuropsychiatric and neurological disorders. Its unique structure and expression pattern make it an attractive target for drug development, as it has the potential to treat a range of neuropsychiatric and neurological disorders. Further studies are needed to fully understand the function and potential of LINC02614 as a drug target.

Protein Name: Long Intergenic Non-protein Coding RNA 2614

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•   general information;
•   protein structure and compound binding;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
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