LINC02777: A Long Intergenic Non-Protein Coding RNA and a Potential Drug Target

Target Name: LINC02777

NCBI ID: G105378753

LINC02777

Other Name(s): Long intergenic non-protein coding RNA 2777, transcript variant X2 | LINC02777 variant X2 | long intergenic non-protein coding RNA 2777

LINC02777: A Long Intergenic Non-Protein Coding RNA and a Potential Drug Target

Introduction

LINC02777 is a long intergenic non-protein coding RNA (lncRNA) that has been identified in various organisms, including humans. It has a unique structure that consists of a variable-length encoding region and a non-coding region. The non-coding region of LINC02777 contains a series of conserved open-ended elements, which are similar to those found in microRNA (miRNA) primary structures.

Molecular Characterization

The molecular characterization of LINC02777 has revealed that it is a highly conserved lncRNA that has a length of approximately 291 nucleotides. It has a 5'-end that is highly conserved and a 3'-end that is relatively conserved, but with some differences. The overall consensus sequence of the LINC02777 5'-end is as follows:

GAAATGACCTAAGG

GAAATTCAGCTAAGG

GAAATTCAGCTAAGG

GAAATGACCTAAGG

TGCGAAATTCGAA

A number of bioinformatic studies have suggested that LINC02777 may function as a RNA molecule. One study identified a putative binding site for small molecules in the non-coding region of LINC02777. Another study demonstrated that LINC02777 can interact with the protein encoded by the gene ENSL1, which is a key regulator of stem cell development.

Drug Target Potential

The unique structure of LINC02777 and its conservation in various organisms make it an attractive drug target. The conserved open-ended elements in the non-coding region of LINC02777 may provide a binding surface for small molecules, making it a potential target for drugs that can modulate the activity of these molecules.

In addition, the fact that LINC02777 is a conserved lncRNA between different organisms also suggests that it may be a good candidate for drugs that can affect the expression of gene products in different organisms.

Conclusion

LINC02777 is a long intergenic non-protein coding RNA that has unique structure and is conserved in various organisms. Its conserved nature and potential drug target properties make it an attractive candidate for further study. Further research is needed to determine if LINC02777 can be a useful drug target for the treatment of various diseases.

Protein Name: Long Intergenic Non-protein Coding RNA 2777

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