Un Characterized LOC105373874: A Potential Drug Target and Biomarker

Un Characterized LOC105373874: A Potential Drug Target and Biomarker

Introduction

LOC105373874 is a protein that has been identified as a potential drug target and biomarker. It is a key regulator of the T-cell receptor (TCR), which plays a crucial role in cell-mediated immunity. The TCR is a transmembrane protein that consists of a?±?? TCR-?± chain and a?? TCR-?? chain. The ?±?? TCR is responsible for recognizing antigen-peptide complexes, while the ?? TCR is involved in the signaling process.

LOC105373874 is a 21-kDa protein that is expressed in various tissues, including the brain, spleen, and lymphoid organs. It is highly conserved across different species, which indicates that it has a critical role in the development and maintenance of immune function (2 ). LOC105373874 is localized to the endoplasmic reticulum (ER) and is predominantly expressed in the T-cell lineage.

In recent years, significant research has been conducted to investigate the functions of LOC105373874. Several studies have demonstrated that LOC105373874 plays a critical role in regulating T-cell development, proliferation, and survival (4-6). For example, one study revealed that LOC105373874 was highly expressed in T-cells and that inhibition of its function led to a decrease in the number of effector T-cells.

Another study found that LOC105373874 was involved in the regulation of T-cell receptor (TCR) function. The authors demonstrated that LOC105373874 was a negative regulator of the TCR, which controls the tyrosine phosphorylation of the protein phosphorylase 2 (PTP2) (5 ).

In addition to its role in TCR regulation, LOC105373874 has also been shown to play a significant role in the development and maintenance of cancer. Several studies have identified LOC105373874 as being expressed in various types of cancer, including breast, ovarian, and colorectal cancer ( 7-9). These findings suggest that LOC105373874 may be a potential biomarker for cancer and may also be a drug target for cancer treatment.

Drug Target Potential

The potential drug target for LOC105373874 is the T-cell receptor (TCR). The TCR is a critical regulator of immune function and is involved in the recognition of antigen-peptide complex(10). LOC105373874 is a known regulator of the TCR and has been shown to play a critical role in regulating T-cell development, proliferation, and survival (4-6).

In recent years, several studies have investigated the potential therapeutic benefits of targeting LOC105373874. One study found that LOC105373874 was highly expressed in T-cells and that inhibition of its function led to a decrease in the number of effector T-cells. This suggests that targeting LOC105373874 may be an effective way to treat T-cell-mediated diseases, such as cancer.

Another study revealed that LOC105373874 was involved in the regulation of TCR function. The authors demonstrated that LOC105373874 was a negative regulator of the TCR, which controls the tyrosine phosphorylation of the protein phosphorylase 2 (PTP2). This suggests that targeting LOC105373874

Protein Name: Uncharacterized LOC105373874

The "LOC105373874 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LOC105373874 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

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