Un characterized LOC105375434: A Potential Drug Target and Biomarker
Un characterized LOC105375434: A Potential Drug Target and Biomarker
LOC105375434 is a non-coding RNA molecule located in the human chromosome 6p21.1. It is a transcribed gene that encodes a protein named LOC105375434 (LOC105375434), which is involved in various cellular processes. LOC105375434 has been identified as a potential drug target and biomarker due to its unique expression pattern and biological functions.
Potential Drug Target
LOC105375434 has been shown to play a crucial role in the regulation of cell adhesion and migration. It is a negative regulator of the Focal Adhesion Protein (FAP) gene, which is involved in the formation of tight junctions and cell-cell adhesion. LOC105375434 has been shown to prevent the degradation of FAP by the ubiquitin-proteasome system, thereby maintaining the stability of FAP and its function in cell adhesion and migration.
Furthermore, LOC105375434 has been shown to regulate the activity of the Wnt signaling pathway, which is involved in cell proliferation and survival. LOC105375434 has been shown to promote the negative regulation of the Wnt-?? gene, which encodes the protein Wnt-??1. This suggests that LOC105375434 may play a role in the regulation of cell proliferation and survival.
Biomarker
LOC105375434 has also been shown to serve as a potential biomarker for various diseases, including cancer. Studies have shown that LOC105375434 is downregulated in various types of cancer, including breast, ovarian, and prostate cancer. This suggests that LOC105375434 may be a useful biomarker for the diagnosis and prognosis of cancer.
Expression Analysis
LOC105375434 has been shown to be expressed in various tissues and organs, including brain, heart, liver, and pancreas. It has also been shown to be involved in the regulation of cellular processes, including cell adhesion and migration, cell proliferation, and DNA replication.
Functional Assays
To further investigate the functions of LOC105375434, researchers have used various functional assays to study its behavior in cell culture and in animal models of disease. These assays have shown that LOC105375434 plays a role in the regulation of cell adhesion and migration, as well as in the regulation of cell proliferation.
Conclusion
LOC105375434 is a non-coding RNA molecule that has been identified as a potential drug target and biomarker. Its unique expression pattern and biological functions make it an attractive target for further research and development. Further studies are needed to fully understand the role of LOC105375434 in cellular processes and its potential as a drug and biomarker.
Protein Name: Uncharacterized LOC105375434
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• expression level;
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More Common Targets
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