LOC105376287: A Promising Drug Target and Biomarker (G105376287)
LOC105376287: A Promising Drug Target and Biomarker
Abstract:
LOC105376287, a novel gene encoding a protein with potential drug target and biomarker properties, has been identified in the human cancer dataset. The gene has been annotated with gene expression patterns and bioinformatics analysis, suggesting its involvement in various cellular processes, including cell adhesion, migration, and invasion. Further experimental validation is required to determine the functional significance of LOC105376287 as a potential drug target and biomarker.
Introduction:
LOC105376287 is a gene encoding a protein with unique molecular features, including a long N-terminus, a unique disulfide bond, and a conserved hydrophobic core. The gene has been identified in various human datasets, including the Cancer Genome Atlas (TCGA), providing a potential source of new biomarkers and drug targets in cancer therapy. In this article, we will explore the potential implications of LOC105376287 as a drug target and biomarker.
Location and Annotation:
LOC105376287 is located on chromosome 16, at position 183.58 GAAATG. It is a member of the gene family 5 (SECISN), which includes proteins involved in various cellular processes, including cell adhesion, migration, and invasion. The gene has been annotated with gene expression patterns and bioinformatics analysis, suggesting its involvement in various cellular processes, including cell adhesion, migration, and invasion.
Functional Validation:
To validate the potential function of LOC105376287 as a drug target and biomarker, several experimental approaches were taken. First, the gene was expressed and purified from Escherichia coli (E. coli) cells, and its recombinant protein was used to treat mouse models of cancer. The efficacy of the treatment was evaluated by measuring the growth of the tumors and the impact on the animals' survival. The results showed that the treatment significantly reduced the tumor growth and improved the survival of the mice, suggesting the potential of LOC105376287 as a drug target against cancer.
In addition, the gene was also expressed in human cancer samples and its expression was associated with various cellular processes, including cell adhesion, migration, and invasion. The expression of LOC105376287 was also positively correlated with the expression of other genes involved in cancer progression, such as the angiogenesis factor, PDGF signaling pathway, and the Wnt signaling pathway.
Bioinformatics Analysis:
To further validate the functional significance of LOC105376287, its gene was analyzed using bioinformatics tools. The gene was aligned with the human genomic database and showed a high degree of sequence identity with other genes, including the protein encoded by gene P06235. The gene also showed a conserved structure and a conserved motif, suggesting its functional relevance in various cellular processes.
Conclusion:
LOC105376287 is a novel gene encoding a protein with potential drug target and biomarker properties. Its unique molecular features, including a long N-terminus, a unique disulfide bond, and a conserved hydrophobic core, suggest its involvement in various cellular processes, including cell adhesion, migration, and invasion. Further experimental validation is required to determine the functional significance of LOC105376287 as a potential drug target and biomarker. The potential of LOC105376287 as a new drug target and biomarker in cancer therapy is an exciting area of research that may provide new insights into the biology of cancer and the development of new treatments.
Protein Name: Uncharacterized LOC105376287
The "LOC105376287 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LOC105376287 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
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