TRMT61A: A promising drug target and biomarker for TRNA methyltransferase-mediated diseases

Target Name: TRMT61A

NCBI ID: G115708

TRMT61A

TRMT61A: A promising drug target and biomarker for TRNA methyltransferase-mediated diseases

Transportive RNA (tRNA) methyltransferase (TRMT) is a key enzyme involved in the regulation of gene expression and translation in eukaryotic cells. Mutations in the TRMT gene have been implicated in a variety of diseases, including cancer, neurodegenerative diseases, and chronic diseases. The TRMT61A gene has been identified as a potential drug target and biomarker for TRNA methyltransferase-mediated diseases.

Diseases associated with TRMT mutations

TRMT is involved in the regulation of essential cellular processes, including splicing, which is the process by which the cell removes non-coding introns from the RNA and joins together the remaining coding regions. Mutations in TRMT genes have been implicated in the development of various diseases, including cancer, neurodegenerative diseases, and chronic diseases.

TRMT mutations have been implicated in the development of various diseases, including:

1. Cancer: Several studies have identified TRMT mutations as being associated with the development of various cancers, including breast, ovarian, and colorectal cancers.
2. Neurodegenerative diseases: TRMT mutations have been implicated in the development of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.
3. Chronic diseases: TRMT mutations have been associated with the development of chronic diseases, including cardiovascular disease, diabetes, and obesity.

TRMT61A as a drug target

TRMT61A is a potential drug target for TRNA methyltransferase-mediated diseases due to its unique structure and function. The TRMT61A gene encodes a protein that has a conserved core domain similar to other TRMTs, as well as a unique N-terminal region that includes a conserved putative RNA methyltransferase domain. The TRMT61A protein has been shown to have unique functions in various cellular processes, including splicing regulation, RNA stability, and DNA methylation.

TRMT61A has been shown to play a role in the regulation of cellular processes that are important for disease development, including splicing regulation, RNA stability, and DNA methylation. Mammalian cells have 23 pairs of exons, and each pair consists of an intron and a corresponding exon. During splicing, the introns are removed from the RNA and the exons are concatenated together to form a functional RNA molecule. TRMT61A is involved in the regulation of splicing by methylating the exons of pre-mRNA.

In addition to its role in splicing regulation, TRMT61A has also been shown to play a role in the regulation of RNA stability and DNA methylation. RNA stability refers to the ability of RNA molecules to resist being removed from the cell. TRMT61A has been shown to regulate the stability of pre-mRNA by methylating the exons, which can prevent the exons from being removed from the RNA molecule.

TRMT61A has also been shown to play a role in DNA methylation. DNA methylation is a process by which methyl groups are added to the promoter region of a gene to prevent gene transcription. TRMT61A has been shown to be involved in the regulation of DNA methylation by methylating the promoter region of pre-mRNA.

TRMT61A as a biomarker

TRMT61A has the potential to serve as a biomarker for TRNA methyltransferase-mediated diseases. The TRMT61A protein has been shown to have unique functions in various cellular processes, including splicing regulation, RNA stability, and DNA methylation. These functions make TRMT61A an attractive target for drug development.

TRMT61A has been shown to be involved in

Protein Name: TRNA Methyltransferase 61A

Functions: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297)

The "TRMT61A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRMT61A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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