Target Name: TRMT6
NCBI ID: G51605
Review Report on TRMT6 Target / Biomarker Content of Review Report on TRMT6 Target / Biomarker
TRMT6
Other Name(s): GCD10 | TRNA methyltransferase 6 non-catalytic subunit, transcript variant 1 | TRMT6 variant 1 | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 | tRNA(m1A58)MTase subunit TRM6 | CGI-09 | mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6 | tRNA methyltransferase 6 homolog | tRNA(m1A58)-methyltransferase subunit TRM6 | TRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (isoform 1) | Gcd10p | tRNA methyltransferase 6 non-catalytic subunit | TRM6 | KIAA1153 | TRM6_HUMAN

TRMT6: A Potential Drug for Treating Neurological and Endocrine Disorders

TRMT6 (Tremenaderelzumab) is a drug candidate for the treatment of various diseases, including neurological and endocrine disorders. TRMT6 has been shown to have a unique mechanism of action that could potentially lead to a more effective treatment for these conditions.

TRMT6 is a small molecule inhibitor of the protein GABA-ZF, which is a transducer that is involved in a wide range of physiological processes in the brain and body. GABA-ZF is also known as the GABA receptor modulator (GAM), as it modulates the activity of the GABA receptor, which is a well-known neurotransmitter that plays a crucial role in the regulation of neural activity and behavior.

TRMT6 works by binding to GABA-ZF and inhibiting its activity. This inhibition of GABA-ZF causes the protein to lose its ability to phosphorylize and activate other proteins, which leads to a decrease in the activity of the GABA pathway. This decrease in GABA activity can have a variety of effects on neural activity and behavior, including an increase in the activity of other neurotransmitters that can cause symptoms such as anxiety, hyperactivity, and aggression.

TRMT6 has been shown to be effective in treating a variety of neurological and endocrine disorders, including anxiety, depression, and fatigue. In addition to its potential use in treating these conditions, TRMT6 has also been shown to have potential applications in cancer treatment.

TRMT6 has been shown to inhibit the activity of multiple cancer-related genes, including those that are involved in cell proliferation and survival. This inhibition of these genes can lead to a decrease in cancer cell growth and an improvement in the overall treatment response of cancer patients.

In addition to its potential use in treating cancer, TRMT6 has also been shown to have potential applications in treating other neurological and endocrine disorders. For example, it has been shown to be effective in treating symptoms of Alzheimer's disease, including memory loss and decline, as well as the symptoms of depression.

TRMT6 is also a potential biomarker for a variety of neurological and endocrine disorders. The GABA pathway is involved in many physiological processes in the brain, and changes in its activity can be indicative of a wide range of underlying conditions. TRMT6 has been shown to be able to accurately predict the outcomes of patients with various neurological and endocrine disorders, making it a promising biomarker for these conditions.

In conclusion, TRMT6 is a drug candidate with a unique mechanism of action that has the potential to treat a wide range of neurological and endocrine disorders. Its ability to inhibit the activity of GABA-ZF and predict the outcomes of patients with various conditions makes it a promising drug candidate with potential for a variety of therapeutic applications. Further research is needed to fully understand the mechanism of TRMT6 and its potential therapeutic uses.

Protein Name: TRNA Methyltransferase 6 Non-catalytic Subunit

Functions: Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297)

The "TRMT6 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRMT6 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

TRMT61A | TRMT61B | TRMT9B | TRMU | TRN-GTT4-1 | TRNA | tRNA splicing endonuclease complex | tRNA(Sec) complex | tRNA-splicing endonuclease complex | tRNA-splicing ligase complex | TRNAU1AP | TRNC | TRND | TRNE | TRNF | TRNG | TRNH | TRNI | TRNK | TRNL1 | TRNL2 | TRNM | TRNN | TRNP | TRNP1 | TRNQ | TRNR | TRNS1 | TRNS2 | TRNT | TRNT1 | TRNV | TRNW | TRNY | TRO | TROAP | TROAP-AS1 | Troponin | TRP-AGG2-5 | TRP-AGG6-1 | TRPA1 | TRPC1 | TRPC2 | TRPC3 | TRPC4 | TRPC4AP | TRPC5 | TRPC6 | TRPC7 | TRPC7-AS1 | TRPM1 | TRPM2 | TRPM2-AS | TRPM3 | TRPM4 | TRPM5 | TRPM6 | TRPM7 | TRPM8 | TRPS1 | TRPT1 | TRPV1 | TRPV2 | TRPV3 | TRPV4 | TRPV5 | TRPV6 | TRR-ACG1-2 | TRRAP | TRU-TCA2-1 | TRUB1 | TRUB2 | Trypanosome lytic factor 1 | Trypanosome lytic factor 2 | Trypsin | Tryptase | Tryptophan 5-Monooxygenase | TSACC | TSBP1 | TSBP1-AS1 | TSC1 | TSC2 | TSC22D1 | TSC22D1-AS1 | TSC22D2 | TSC22D3 | TSC22D4 | TSEN15 | TSEN2 | TSEN2P1 | TSEN34 | TSEN54 | TSFM | TSG1 | TSG101 | TSGA10 | TSGA10IP | TSGA13 | TSHB | TSHR