Target Name: CSF1R
NCBI ID: G1436
Review Report on CSF1R Target / Biomarker Content of Review Report on CSF1R Target / Biomarker
CSF1R
Other Name(s): CSF-1 receptor | Proto-oncogene c-Fms | Colony stimulating factor 1 receptor, transcript variant 1 | CSF1R variant 2 | Macrophage colony stimulating factor I receptor | 2906445 | CSF1R variant 4 | Macrophage colony-stimulating factor 1 receptor | CSF-1-R | Colony stimulating factor 1 receptor, transcript variant 2 | FIM2 | colony stimulating factor 1 receptor | OTTHUMP00000224093 | OTTHUMP00000160525 | CSF-1R | CSFR1 | macrophage colony stimulating factor I receptor | proto-oncogene c-Fms | HDLS1 | C-FMS | Colony stimulating factor 1 receptor, transcript variant 4 | FMS | Macrophage colony-stimulating factor 1 receptor (isoform a) | BANDDOS | FMS proto-oncogene | CSFR | M-CSF-R | HDLS | CSF1R variant 1 | CSF1R_HUMAN | CD115 | McDonough feline sarcoma viral (v-fms) oncogene homolog | c-FMS | CD115 antigen | Colony stimulating factor 1 receptor (CSF1R)

CSF1R: A Promising Drug Target and Biomarker for the Treatment of Central Nervous System Disorders

The central nervous system (CNS) is a complex and dynamic system that plays a crucial role in the regulation of various physiological processes in the body. One of the key challenges in the treatment of CNS disorders is the development of resistance to medications, which can lead to a decline in treatment effectiveness. To address this issue, there is a growing interest in identifying new drug targets and biomarkers that can aid in the development of more effective therapies. In this article, we will focus on the CSF1R receptor, which has been identified as a promising drug target and biomarker for the treatment of CNS disorders.

The CSF1R Receptor

The CSF1R receptor is a transmembrane protein that is expressed in various tissues, including the brain, spinal cord, and peripheral nerves. It is a G protein-coupled receptor (GPCR), which means that it consists of a extracellular domain that is involved in cell signaling, and a transmembrane domain that is responsible for channeling signaling messages into the cell. The CSF1R receptor has been shown to play a role in the regulation of various physiological processes, including pain perception, anxiety, and inflammation.

Drug Targeting

The CSF1R receptor is a potential drug target due to its involvement in several CNS disorders. One of the main reasons for its potential as a drug target is its involvement in pain perception. Pain is a highly unpleasant sensation that can be caused by various factors, including tissue injury, inflammation, and disease. The CSF1R receptor has been shown to play a role in the regulation of pain perception, which suggests that it may be a useful target for the treatment of pain disorders.

Another potential drug target for the CSF1R receptor is its involvement in anxiety and depression. The CSF1R receptor has been shown to play a role in the regulation of anxiety and depression, which suggests that it may be a useful target for the treatment of these disorders. Additionally, the CSF1R receptor has also been implicated in the regulation of inflammation, which makes it a potential target for the treatment of inflammatory CNS disorders.

Biomarker

The CSF1R receptor is also a potential biomarker for the treatment of CNS disorders. The development of biomarkers for the treatment of CNS disorders has the potential to improve the accuracy and effectiveness of diagnostic tests and to identify new therapeutic approaches. The CSF1R receptor has been shown to be a potential biomarker for the treatment of various CNS disorders, including pain, anxiety, and depression.

Targeting

The CSF1R receptor is a GPCR, which means that it consists of a transmembrane domain that is involved in the regulation of intracellular signaling processes. This means that the CSF1R receptor can be targeted by small molecules, such as drugs, which can interact with its transmembrane domain. Currently, there are several drug compounds that have been shown to be potential CSF1R receptor antagonists, which can be used to treat various CNS disorders.

Conclusion

In conclusion, the CSF1R receptor is a promising drug target and biomarker for the treatment of CNS disorders. Its involvement in the regulation of pain, anxiety, and inflammation makes it a potential target for the treatment of various disorders that affect the CNS. Currently, there are several drug compounds that have been shown to be potential CSF1R receptor antagonists, which can be used to treat various CNS disorders. Further research is needed to fully understand the CSF1R receptor's role in the treatment of CNS disorders and to develop more effective therapies.

Protein Name: Colony Stimulating Factor 1 Receptor

Functions: Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway (PubMed:20504948, PubMed:30982609). Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor. In the central nervous system, may play a role in the development of microglia macrophages (PubMed:30982608)

The "CSF1R Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CSF1R comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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