CSPG4: A Promising Drug Target and Biomarker for Diseases (G1464)

Target Name: CSPG4

NCBI ID: G1464

CSPG4

CSPG4: A Promising Drug Target and Biomarker for Diseases

CSPG4 (CSPG4_HUMAN) is a protein that is expressed in human tissues and is known for its role in the development and progression of various diseases, including cancer. CSPG4 has also been identified as a potential drug target and biomarker for several diseases, making it an important player in the field of pharmacology.

CSPG4 is a member of the superfamily of cysteine-rich proteins (SRP), which are a group of transmembrane proteins that contain a characteristic cysteine residue. This protein is known to have multiple unique features that make it a promising candidate for drug targeting, including its ability to interact with a variety of different drugs, its high stability and stability in the body, and its unique expression patterns across different tissues.

One of the key features of CSPG4 is its ability to interact with a variety of different drugs, making it a potentially attractive drug target for a range of diseases. CSPG4 has been shown to interact with a variety of different drugs, including small molecules, peptides, and proteins, making it a versatile target for drug development.

In addition to its potential as a drug target, CSPG4 has also been identified as a potential biomarker for several diseases. For example, CSPG4 has been shown to be overexpressed in a variety of cancer tissues and has been used as a biomarker for cancer diagnosis and treatment. Additionally, CSPG4 has been shown to be expressed in the blood vessels of individuals with cardiovascular disease and has been used as a potential biomarker for this disease.

Another potential use of CSPG4 as a drug target is its role in the development and progression of neurodegenerative diseases. CSPG4 has been shown to be expressed in the brains of individuals with Alzheimer's disease and other neurodegenerative diseases, and has been linked to the development of these diseases. Additionally, studies have shown that inhibiting CSPG4 activity may be a potential approach for treating neurodegenerative diseases.

In addition to its potential as a drug target and biomarker, CSPG4 is also of interest to researchers due to its unique expression patterns across different tissues. CSPG4 is highly expressed in the brain and nervous system, and is also expressed in other tissues such as the heart, lungs, and kidneys. This makes it an attractive candidate for drug targeting studies and for investigating the mechanisms underlying its unique expression patterns across different tissues.

Overall, CSPG4 is a protein that has the potential to be a drug target and biomarker for a variety of diseases. Its unique features, including its ability to interact with a variety of different drugs and its high stability in the body, make it an attractive candidate for drug development studies. Additionally, its unique expression patterns across different tissues make it a promising candidate for investigating the mechanisms underlying its expression and function. Further research is needed to fully understand the potential of CSPG4 as a drug target and biomarker.

Protein Name: Chondroitin Sulfate Proteoglycan 4

Functions: Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades

The "CSPG4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CSPG4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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