Target Name: AADACP1
NCBI ID: G201651
Review Report on AADACP1 Target / Biomarker Content of Review Report on AADACP1 Target / Biomarker
AADACP1
Other Name(s): Arylacetamide deacetylase pseudogene 1 | arylacetamide deacetylase pseudogene 1

AADACP1: A Promising Drug Target and Biomarker for ALS-related Neuronal Degeneration

Amyloidosis, a neurodegenerative disorder characterized by the accumulation of misfolded and aggregated 尾-amyloid peptides, is one of the most common causes of protein misfolding diseases, including Alzheimer's disease (AD). The loss of function of neurons in this condition is believed to be caused by the presence of 尾-amyloid peptides and their aggregation, leading to neurofibrillary tangles and the formation of neuroglial cells that attempt to remove the 尾-amyloid peptides but ultimately contribute to neurodegeneration.

Recent studies have identified several potential drug targets and biomarkers for ALS-related neuronal degeneration, and one of them is AADACP1, a pseudogene encoding for the enzyme arylacetamide deacetylase (AADACP1). In this article, we will discuss the current research on AADACP1 as a drug target and biomarker for ALS-related neuronal degeneration.

The Role of AADACP1 in ALS-related Neuronal Degeneration

Several studies have demonstrated that AADACP1 is involved in the pathogenesis of ALS-related neuronal degeneration. AADACP1 is highly expressed in the brains of individuals with ALS, and its expression is associated with the negative expression of survival motor neuron (SMN) gene, which encodes a protein that is essential for the survival of motor neurons.

In addition, AADACP1 has been shown to play a role in the production of 尾-amyloid peptides, which are believed to contribute to the neurofibrillary tangles and neurodegeneration in ALS. Studies have shown that AADACP1 is able to convert tryptophan, a protein that is normally resistant to 尾-amyloid formation, into 尾-amyloid peptides. This conversion process is thought to be a key step in the production of 尾-amyloid peptides.

Furthermore, AADACP1 has been shown to interact with the protein heat shock protein (HSP70), which is also involved in the production of 尾-amyloid peptides. This interaction between AADACP1 and HSP70 suggests that HSP70 may play a role in the regulation of 尾-amyloid peptide production by AADACP1.

Potential Therapeutic Strategies for AADACP1

Given the involvement of AADACP1 in the pathogenesis of ALS-related neuronal degeneration, there is significant potential for targeting this protein as a therapeutic strategy. Several studies have shown that inhibiting AADACP1 activity can protect motor neurons from the neurotoxicity of 尾-amyloid peptides, suggesting that AADACP1 may be an effective target for the treatment of ALS.

One of the potential strategies for targeting AADACP1 is the use of small molecules that can inhibit AADACP1 activity. Several studies have shown that inhibitors of AADACP1, such as 尾-amyloid peptides, can reverse the neurotoxicity of 尾-amyloid peptides in ALS animal models. These studies have led to the identification of several potential small molecules that may be useful as therapeutic agents for ALS.

Another potential strategy for targeting AADACP1 is the use of drugs that can modulate the expression of AADACP1. Several studies have shown that modulation of AADACP1 expression can be an effective way

Protein Name: Arylacetamide Deacetylase Pseudogene 1

The "AADACP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about AADACP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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AADAT | AAGAB | AAK1 | AAMDC | AAMP | AANAT | AAR2 | AARD | AARS1 | AARS2 | AARSD1 | AASDH | AASDHPPT | AASS | AATBC | AATF | AATK | ABALON | ABAT | ABCA1 | ABCA10 | ABCA11P | ABCA12 | ABCA13 | ABCA17P | ABCA2 | ABCA3 | ABCA4 | ABCA5 | ABCA6 | ABCA7 | ABCA8 | ABCA9 | ABCB1 | ABCB10 | ABCB11 | ABCB4 | ABCB5 | ABCB6 | ABCB7 | ABCB8 | ABCB9 | ABCC1 | ABCC10 | ABCC11 | ABCC12 | ABCC13 | ABCC2 | ABCC3 | ABCC4 | ABCC5 | ABCC6 | ABCC6P1 | ABCC6P2 | ABCC8 | ABCC9 | ABCD1 | ABCD2 | ABCD3 | ABCD4 | ABCE1 | ABCF1 | ABCF1-DT | ABCF2 | ABCF3 | ABCG1 | ABCG2 | ABCG4 | ABCG5 | ABCG8 | ABHD1 | ABHD10 | ABHD11 | ABHD11-AS1 | ABHD12 | ABHD12B | ABHD13 | ABHD14A | ABHD14B | ABHD15 | ABHD16A | ABHD16B | ABHD17A | ABHD17AP1 | ABHD17AP4 | ABHD17AP5 | ABHD17AP6 | ABHD17B | ABHD17C | ABHD18 | ABHD2 | ABHD3 | ABHD4 | ABHD5 | ABHD6 | ABHD8 | ABI1 | ABI2 | ABI3 | ABI3BP