CTC1: A Protein Implicated in Cancer Progression (G80169)

Target Name: CTC1

NCBI ID: G80169

CTC1

CTC1: A Protein Implicated in Cancer Progression

CTC1 (CTC1_HUMAN), also known as human Exploration of Cancer1, is a glycoprotein located on the surface of cancer cells. It is a transmembrane protein that plays a crucial role in cell signaling, particularly in the regulation of cell adhesion, angiogenesis, and cancer progression.

CTC1 is a protein that is expressed in almost all human tissues and has been implicated in the development and progression of many types of cancer. Its expression has been associated with cancer-related survival, and it has been used as a biomarker for several types of cancer, including breast, ovarian, and colorectal cancers.

One of the key functions of CTC1 is its role in cell adhesion. CTC1 is a strong adhesion molecule that is involved in the formation of tight junctions, which are a type of cell-cell adhesion that helps to maintain tissue structure and prevent tissue from coming into contact with the surrounding environment.

In cancer, the regulation of cell adhesion is often disrupted, leading to the development of a more invasive and migratory phenotype. This is thought to contribute to the development of cancer stem cells, which are cancer cells that have the ability to self-renew and promote the growth and spread of cancer.

CTC1 has also been shown to be involved in the regulation of angiogenesis, the process by which new blood vessels are formed to supply oxygen and nutrients to the developing tumors. The deregulation of angiogenesis is a common feature of cancer, and it is thought to contribute to the development and progression of cancer.

In addition to its role in cell adhesion and angiogenesis, CTC1 has also been shown to be involved in the regulation of cancer progression. For example, studies have shown that CTC1 is involved in the regulation of theNotch signaling pathway, a pathway that is involved in the regulation of cell proliferation and survival.

The Notch signaling pathway is a highly conserved signaling pathway that is involved in the regulation of many types of biological processes, including cell growth, differentiation, and survival. It is thought to play a key role in the development and progression of cancer, and it is a potential target for the development of cancer therapies.

The role of CTC1 in the Notch signaling pathway is thought to be related to its ability to regulate the activity of theNotch receptor, a protein that is involved in the regulation of cell survival and proliferation. Studies have shown that CTC1 plays a role in the regulation of theNotch receptor, and that its activity is influenced by the Notch signaling pathway.

In conclusion, CTC1 is a protein that is involved in the regulation of cell adhesion, angiogenesis, and cancer progression. Its role in these processes makes it a potential drug target or biomarker for the development of cancer therapies. Further research is needed to fully understand the role of CTC1 in cancer biology, and to develop effective therapies that target this protein.

Protein Name: CST Telomere Replication Complex Component 1

Functions: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097). Involved in telomere maintenance (PubMed:19854131, PubMed:22863775). Involved in genome stability (PubMed:22863775). May be in involved in telomeric C-strand fill-in during late S/G2 phase (By similarity)

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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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