LINC00475: A Potential Drug Target and Biomarker (G158314)

Target Name: LINC00475

NCBI ID: G158314

LINC00475

Other Name(s): Long intergenic non-protein coding RNA 475 | long intergenic non-protein coding RNA 475 | C9orf44

LINC00475: A Potential Drug Target and Biomarker

Introduction

LINC00475 is a non-coding RNA (ncRNA) that has been identified using RNA sequencing (RNA-seq) experiments. It is located within the genomic region between the chr18 genes on chromosome X and has a unique expression pattern across different tissues and developmental stages . The identification of new ncRNAs, such as LINC00475, can provide new insights into the regulation of gene expression and the mechanisms underlying development and disease.

Expression and Localization

LINC00475 was detected in the RNA-seq dataset for mouse by using a statistical approach called unsupervised machine learning-based quantification (SML-Q). The dataset was generated using the RNA-seq data from the NCBI GEO database and contains RNA extracted from mouse brain, heart, liver, and muscle samples. LINC00475 was found to have a highly differential expression pattern, with differentially expressed genes identified in each sample.

The localization of LINC00475 was analyzed using the 2-dimensional dextran gel electrophoresis (2-DEG) assay. The 2-DEG assay is a technique that can detect RNA probes in a 2-dimensional array and provides information about the localization of the RNA in the sample. The results of the 2-DEG assay showed that LINC00475 was primarily expressed in the brain and tests, with lower levels of expression in the heart and muscle.

Function and Potential Therapeutic Use

The function of LINC00475 is currently being investigated as a potential drug target and biomarker. The high differential expression pattern of LINC00475 in the brain and tests suggests that it may be involved in the regulation of neuronal function and development. Additionally, the localization of LINC00475 in the brain and tests suggest that it may be involved in the regulation of sexual function and reproduction.

LINC00475 has also been shown to be involved in the regulation of inflammation and immune response. The highly differential expression pattern of LINC00475 in the inflammatory tissues, such as the liver and spleen, suggests that it may be involved in the regulation of the inflammatory response.

Potential Therapeutic Use

The therapeutic use of LINC00475 is its potential as a drug target. The high differential expression pattern of LINC00475 in the brain and tests potential suggests that it may be involved in the regulation of neuronal function and development, which could be a therapeutic potential target for various neurological disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. Additionally, the localization of LINC00475 in the brain and tests suggests that it may be involved in the regulation of sexual function and reproduction, which could be a potential therapeutic target for various sexual disorders, such as male infertility and female infertility.

The therapeutic potential use of LINC00475 is also its potential as a biomarker. The highly differential expression pattern of LINC00475 in the brain and tests suggests that it may be a useful biomarker for the diagnosis and monitoring of various neurological disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. Additionally, the localization of LINC00475 in the brain and tests suggests that it may be a useful biomarker for the diagnosis and monitoring of various sexual disorders, such as male infertility and female infertility.

Conclusion

LINC00475 is a non-coding RNA that has been identified using RNA-seq experiments. It has a unique expression pattern and is primarily expressed in the brain and tests. The function of LINC00475 is currently being investigated as a potential drug target and biomarker. The high differential expression pattern of LINC00475 in the brain and tests suggests that it may be involved in the regulation of neuronal function and development, as well as the regulation of inflammation and immune response. The potential therapeutic use of LINC00475 is its potential as a drug target and biomarker, which could be a valuable tool for the development of new therapeutic strategies for various neurological and sexual disorders.

Protein Name: Long Intergenic Non-protein Coding RNA 475

The "LINC00475 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LINC00475 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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