Target Name: ZNF497
NCBI ID: G162968
Review Report on ZNF497 Target / Biomarker Content of Review Report on ZNF497 Target / Biomarker
ZNF497
Other Name(s): Zinc finger protein 497, transcript variant 1 | Zinc finger protein 497 | zinc finger protein 497 | zinc finger-like protein | Zinc finger-like protein | ZN497_HUMAN | ZNF497 variant 1

Introduction to ZNF497, A Potential Drug Target

ZNF497 is a unique zinc finger protein that has recently gained attention as a potential drug target and biomarker in various diseases. This article explores the role of ZNF497 in human health and highlights its potential as a therapeutic target.

What is ZNF497?

ZNF497, also known as Zinc finger protein 497, is a transcription factor that belongs to the Kr眉ppel-associated box domain-zinc finger protein (KRAB-ZFP) family. It was first identified in the early 2000s and is located on chromosome 20q13.3. ZNF497 contains a typical C2H2-type zinc finger domain, which is known to play a critical role in DNA binding and transcriptional regulation.

Transcriptional Regulation by ZNF497

ZNF497 acts as a transcriptional regulator that interacts with DNA and influences gene expression. Its zinc finger domain allows it to bind to specific DNA sequences and recruit various cofactors to activate or repress gene transcription. By controlling the expression of target genes, ZNF497 plays a crucial role in the development, differentiation, and homeostasis of various tissues.

Implications in Cancer

Recent studies have implicated ZNF497 in cancer development and progression. Alterations in ZNF497 expression have been observed in several types of cancer, including breast, lung, and colorectal cancers. In some cases, upregulation of ZNF497 has been associated with tumor growth and poor clinical outcomes, while downregulation has been linked to tumor suppressive effects.

Potential as a Therapeutic Target

The dysregulation of ZNF497 in cancer makes it an attractive therapeutic target. Researchers are actively exploring the potential of small molecule inhibitors and gene therapy approaches to modulate ZNF497 expression and activity. By manipulating ZNF497 levels, it may be possible to inhibit tumor growth or sensitize cancer cells to conventional therapies.

Role in Developmental Disorders

ZNF497 has also been implicated in various developmental disorders, such as intellectual disability and autism spectrum disorders. Mutations in the ZNF497 gene have been identified in individuals with neurodevelopmental disabilities, suggesting a crucial role in brain development and function. Experimental studies using animal models have further supported the involvement of ZNF497 in neurodevelopment.

Potential as a Biomarker

The dysregulation of ZNF497 in diseases, including cancer and developmental disorders, makes it a promising biomarker. By measuring the levels of ZNF497 in patient samples, such as blood or tissue biopsies, clinicians could potentially diagnose and monitor the progression of various diseases. Additionally, ZNF497 levels could serve as an indicator of treatment response, allowing personalized therapy approaches.

Conclusion

ZNF497 is an intriguing zinc finger protein that plays a crucial role in transcriptional regulation and gene expression. Its dysregulation has been associated with various diseases, including cancer and developmental disorders. The potential of ZNF497 as a therapeutic target and biomarker opens up new avenues for understanding disease mechanisms and designing personalized treatment strategies. Further research on ZNF497 will undoubtedly shed more light on its function and therapeutic potential in the future.

Protein Name: Zinc Finger Protein 497

Functions: May be involved in transcriptional regulation

The "ZNF497 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF497 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

ZNF497-AS1 | ZNF500 | ZNF501 | ZNF502 | ZNF503 | ZNF503-AS1 | ZNF503-AS2 | ZNF506 | ZNF507 | ZNF510 | ZNF511 | ZNF512 | ZNF512B | ZNF513 | ZNF514 | ZNF516 | ZNF516-DT | ZNF517 | ZNF518A | ZNF518B | ZNF519 | ZNF519P3 | ZNF521 | ZNF524 | ZNF525 | ZNF526 | ZNF527 | ZNF528 | ZNF528-AS1 | ZNF529 | ZNF529-AS1 | ZNF530 | ZNF532 | ZNF534 | ZNF536 | ZNF540 | ZNF541 | ZNF542P | ZNF543 | ZNF544 | ZNF546 | ZNF547 | ZNF548 | ZNF549 | ZNF550 | ZNF551 | ZNF552 | ZNF554 | ZNF555 | ZNF556 | ZNF557 | ZNF558 | ZNF559 | ZNF559-ZNF177 | ZNF560 | ZNF561 | ZNF561-AS1 | ZNF562 | ZNF563 | ZNF564 | ZNF565 | ZNF566 | ZNF566-AS1 | ZNF567 | ZNF568 | ZNF569 | ZNF56P | ZNF57 | ZNF570 | ZNF571 | ZNF571-AS1 | ZNF572 | ZNF573 | ZNF574 | ZNF575 | ZNF576 | ZNF577 | ZNF578 | ZNF579 | ZNF580 | ZNF582 | ZNF582-DT | ZNF583 | ZNF584 | ZNF585A | ZNF585B | ZNF586 | ZNF587 | ZNF587B | ZNF589 | ZNF592 | ZNF593 | ZNF594 | ZNF594-DT | ZNF595 | ZNF596 | ZNF597 | ZNF598 | ZNF599 | ZNF600