Target Name: ZNF598
NCBI ID: G90850
Review Report on ZNF598 Target / Biomarker Content of Review Report on ZNF598 Target / Biomarker
ZNF598
Other Name(s): Zinc finger protein 598, E3 ubiquitin ligase | ZN598_HUMAN | HEL2 | zinc finger protein 598 | zinc finger protein 598, E3 ubiquitin ligase | E3 ubiquitin-protein ligase ZNF598

ZNF598: A Potential Drug Target and Biomarker for the Treatment of Neurodegenerative Disorders

Introduction

Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease are progressive diseases that affect the brain and are characterized by the progressive loss of nerve cells and the damage of neural circuits. These disorders are a major burden on society and have a significant impact on the quality of life of individuals and their families.

ZNF598: A Potential Drug Target

ZNF598 is a protein that is expressed in various tissues and has been identified as a potential drug target for the treatment of neurodegenerative disorders. ZNF598 is a zinc finger protein that belongs to the subfamily of zinc finger proteins (SFP/ZNF), which are a family of evolutionarily conserved proteins that play a central role in the regulation of gene expression and are involved in a wide range of cellular processes.

SFP/ZNF proteins are characterized by the presence of a zinc finger domain, which is a conserved structural feature that is characterized by the presence of a central conserved ion in the protein's active site. This ion plays a critical role in the regulation of protein stability and function and is involved in the formation of protein-protein interactions and in the regulation of cellular processes such as cell growth, differentiation, and inflammation.

ZNF598 has been shown to be involved in the regulation of gene expression and has been implicated in the development and progression of neurodegenerative disorders. For example, studies have shown that ZNF598 is involved in the regulation of the expression of genes that are involved in the development of neurodegenerative disorders, such as the genes involved in the production of neurotransmitters that are involved in the regulation of mood, appetite, and movement.

In addition, ZNF598 has also been shown to be involved in the regulation of the structure and stability of neurons, which is important for the function of the nervous system. Studies have shown that ZNF598 plays a role in the regulation of the cytoskeleton and in the maintenance of the integrity of the neural cytoskeleton, which is important for the proper functioning of the nervous system.

ZNF598 as a Potential Biomarker

One of the challenges in the treatment of neurodegenerative disorders is the lack of effective biomarkers that can be used to monitor the progression of the disease and the effectiveness of treatments. ZNF598 may be a potential biomarker for the treatment of neurodegenerative disorders because it is involved in the regulation of gene expression and has been shown to be involved in the development and progression of these disorders.

Studies have shown that the expression of ZNF598 is decreased in the brains of individuals with neurodegenerative disorders, which may be an indication that the expression of ZNF598 is involved in the development of these disorders. Additionally, studies have shown that the levels of ZNF598 have been Correlated with the severity of neurodegenerative disorders, which may be an indication that ZNF598 is involved in the regulation of the progression of these disorders.

In addition to its potential as a biomarker, ZNF598 may also be a useful drug target for the treatment of neurodegenerative disorders. Studies have shown that ZNF598 is involved in the regulation of gene expression and has been shown to play a role in the development and progression of neurodegenerative disorders. This suggests that targeting ZNF598 with small molecules or other compounds may be a promising strategy for the treatment of these disorders.

Conclusion

ZNF598 is a protein that has been identified as a potential drug target for the treatment of neurodegenerative disorders. Its involvement in the regulation of gene expression and its association with the development and progression of these disorders make it an attractive target for the development of new treatments for these disorders. Further research is needed to

Protein Name: Zinc Finger Protein 598, E3 Ubiquitin Ligase

Functions: E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation (PubMed:28065601, PubMed:28132843). Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10, RPS20/uS10 and RPS3/uS3 (PubMed:28065601, PubMed:28132843). Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843). Also acts as a component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931)

The "ZNF598 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF598 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

ZNF599 | ZNF600 | ZNF603P | ZNF605 | ZNF606 | ZNF607 | ZNF608 | ZNF609 | ZNF610 | ZNF611 | ZNF613 | ZNF614 | ZNF615 | ZNF616 | ZNF618 | ZNF619 | ZNF620 | ZNF621 | ZNF622 | ZNF623 | ZNF624 | ZNF625 | ZNF625-ZNF20 | ZNF626 | ZNF627 | ZNF628 | ZNF629 | ZNF630 | ZNF638 | ZNF639 | ZNF641 | ZNF644 | ZNF646 | ZNF648 | ZNF649 | ZNF652 | ZNF652-AS1 | ZNF653 | ZNF654 | ZNF655 | ZNF658 | ZNF658B | ZNF66 | ZNF660 | ZNF662 | ZNF663P | ZNF664 | ZNF664-RFLNA | ZNF665 | ZNF667 | ZNF667-AS1 | ZNF668 | ZNF669 | ZNF670 | ZNF670-ZNF695 | ZNF671 | ZNF672 | ZNF674 | ZNF674-AS1 | ZNF675 | ZNF676 | ZNF677 | ZNF678 | ZNF679 | ZNF680 | ZNF681 | ZNF682 | ZNF683 | ZNF684 | ZNF687 | ZNF688 | ZNF689 | ZNF69 | ZNF691 | ZNF692 | ZNF695 | ZNF696 | ZNF697 | ZNF699 | ZNF7 | ZNF70 | ZNF700 | ZNF701 | ZNF702P | ZNF703 | ZNF704 | ZNF705A | ZNF705B | ZNF705CP | ZNF705EP | ZNF705G | ZNF706 | ZNF707 | ZNF708 | ZNF709 | ZNF71 | ZNF710 | ZNF711 | ZNF713 | ZNF714