Target Name: ZNF587B
NCBI ID: G100293516
Review Report on ZNF587B Target / Biomarker Content of Review Report on ZNF587B Target / Biomarker
Other Name(s): ZNF587B variant 2 | Zinc finger protein 587B | Z587B_HUMAN | Zinc finger protein 587B (isoform 2) | zinc finger protein 587B | Zinc finger protein 587B, transcript variant 2

ZNF587B: A Potential Drug Target and Biomarker

Zinc finger proteins (ZFPs) are a family of transmembrane proteins that play a crucial role in various cellular processes. One of the ZFPs, ZNF587B, has been identified as a potential drug target and biomarker. This article will discuss the ZNF587B protein, its function, potential drug targets, and potential applications as a biomarker.

Function of ZNF587B

ZNF587B is a 21-kDa protein that is expressed in various tissues, including brain, heart, liver, and pancreas. It is a component of the ZNF2 complex, which is a transcription factor that regulates various cellular processes, including cell growth, differentiation, and DNA replication.

The ZNF2 complex plays a crucial role in the development and maintenance of neural stem cells (NSCs). NSCs are a crucial source of cells with the potential to differentiate into different neural cell types, including neurons and glial cells. The ZNF2 complex is required for the proliferation and survival of NSCs, and it has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease.

Potential Drug Targets

ZNF587B is a potential drug target due to its involvement in the ZNF2 complex. The ZNF2 complex is a complex protein that consists of various subunits, including ZNF587B. ZNF587B has been shown to interact with various transcription factors, including SMAD3,p63, and p53. These interactions suggest that ZNF587B may be a regulatory protein that plays a role in the ZNF2 complex.

ZNF587B can be targeted by small molecules, including inhibitors of the protein's phosphorylation or inhibitors of its interaction with other transcription factors. Some small molecules that have been shown to interact with ZNF587B include inhibitors of the protein's tyrosine phosphorylation, such as negative modulators (SMAs) and inhibitors of the protein's interaction with p53, such as inhibitors of the protein's tyrosine phosphorylation or inhibitors of the protein's interaction with the transcription factor p53.

Potential Applications as a Biomarker

ZNF587B has the potential to be used as a biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. The ZNF2 complex is involved in the development and maintenance of neural stem cells, and alterations in the ZNF2 complex have been implicated in the development and progression of various neurological disorders.

Studies have shown that changes in the ZNF2 complex have been associated with the development of various diseases, including Alzheimer's disease, Parkinson's disease, and other neurological disorders. For example, studies have shown that individuals with certain genetic mutations, such as those in the ZNF2 gene, are at increased risk for developing Alzheimer's disease.

In addition, alterations in the ZNF2 complex have also been implicated in the development and progression of neurodegenerative diseases, such as Parkinson's disease and Huntington's disease. These diseases are characterized by the progressive loss of motor and cognitive function, and they are some of the most common causes of disability and cognitive impairment in the elderly.


ZNF587B is a protein that is involved in the ZNF2 complex and has been shown to play a role in the development and maintenance of neural stem cells. Its potential drug targets and biomarker applications make it an attractive target for researchers and clinicians. Further studies are needed to fully understand the role of ZNF587B in the ZNF2 complex and its potential as a drug

Protein Name: Zinc Finger Protein 587B

Functions: May be involved in transcriptional regulation

The "ZNF587B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF587B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at

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