DLG4: A Potential Drug Target and Biomarker (G1742)

Target Name: DLG4

NCBI ID: G1742

DLG4

DLG4: A Potential Drug Target and Biomarker

DLG4 (doublecortin) is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and gastrointestinal tract. It is a member of the superfamily of structurally similar cytoskeletal proteins, known as the kinesin-67 family. DLG4 has been shown to play a role in various physiological processes, including cell migration, cell survival, and tissue repair.

The search for potential drug targets and biomarkers is a critical aspect of modern medicine. Drug targets are proteins that are involved in the development and progression of diseases, while biomarkers are proteins that are associated with the presence or absence of a disease. DLG4 is a potential drug target and biomarker due to its involvement in various physiological processes and its expression in a variety of tissues.

One of the key features of DLG4 is its role in cell migration and cell survival. Cell migration is a critical process that allows cells to move to their desired locations in the body and participate in tissue repair and regeneration. DLG4 has been shown to be involved in the regulation of cell migration by interacting with the protein T-cadherin. T-cadherin is a transmembrane protein that is involved in cell-cell adhesion and is composed of two transmembrane subunits. The interaction between DLG4 and T-cadherin has been shown to play a role in the regulation of cell migration and the development of various diseases, including cancer.

Another function of DLG4 is its role in cell survival. Cell survival is a critical process that allows cells to maintain their integrity and survive in the face of various stressors, including those that are caused by diseases. DLG4 has been shown to be involved in the regulation of cell survival by interacting with the protein p53, which is a well-known protein that is involved in the regulation of DNA replication and cell survival. The interaction between DLG4 and p53 has been shown to play a role in the regulation of cell survival and the development of various diseases, including cancer.

In addition to its role in cell migration and cell survival, DLG4 is also involved in the regulation of tissue repair and regeneration. Tissue repair and regeneration are critical processes that allow the body to repair damaged tissue and replace it with new tissue after injury or disease. DLG4 has been shown to be involved in the regulation of tissue repair and regeneration by interacting with the protein transforming growth factor-beta (TGF-beta). TGF-beta is a cytoskeleton protein that is involved in the regulation of cell growth, differentiation, and repair. The interaction between DLG4 and TGF-beta has been shown to play a role in the regulation of tissue repair and regeneration and the development of various diseases, including cancer.

DLG4 is also involved in the regulation of cell signaling pathways. Cell signaling pathways are the networks of chemical reactions that occur inside cells, allowing cells to communicate with one another and to respond to various stimuli. DLG4 has been shown to be involved in the regulation of cell signaling pathways by interacting with the protein SHC1. SHC1 is a cytoskeleton protein that is involved in the regulation of cell signaling pathways, including the regulation of cell growth and differentiation.

In conclusion, DLG4 is a protein that is involved in various physiological processes, including cell migration, cell survival, tissue repair and regeneration, and cell signaling pathways. As a potential drug target and biomarker, DLG4 is an attractive target for researchers to investigate and develop new treatments for a variety of diseases. Further research is needed to fully understand the role of DLG4 in various biological processes and to develop effective treatments based on its potential as a drug target and biomarker.

Protein Name: Discs Large MAGUK Scaffold Protein 4

Functions: Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (PubMed:26334723)

The "DLG4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DLG4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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