DMTF1-AS1: A Potential Drug Target and Biomarker (G101927420)

Target Name: DMTF1-AS1

NCBI ID: G101927420

DMTF1-AS1

Other Name(s): DMTF1 antisense RNA 1, transcript variant 1 | DMTF1 antisense RNA 1

DMTF1-AS1: A Potential Drug Target and Biomarker

DMTF1-AS1 (doublecortin-like peptide 1-alpha-syntactylase 1) is a non-coding RNA molecule that has been identified as a potential drug target and biomarker. The molecule is derived from the doublecortin gene, which encodes a protein involved in the detoxification of xenobiotics and other harmful substances. The doublecortin gene has four splice variants, including DMTF1-AS1, which has been shown to have unique functions in various cellular processes.

DMTF1-AS1 is a 24.1-kb RNA molecule that contains 19 unique exons. The molecule has a calculated molecular weight of 6.9 kDa and a predicted localization in the endoplasmic reticulum (ER) and nuclear pore complex (NPC). The ER and NPC are responsible for the delivery and processing of proteins, including potential drug targets, to their respective destinations. The unique exons and predicted localization of DMTF1-AS1 suggest that it may play a significant role in the regulation of cellular processes, including drug response and metabolism.

DMTF1-AS1 has been shown to have various functions in cell-based assays. For example, the molecule has been shown to enhance the sensitivity of cancer cells to chemotherapy drugs, suggesting that it may have potential as a cancer therapeutic. Additionally, the molecule has been shown to promote the growth of brain cells, which may indicate that it has potential as a neuroprotective agent.

DMTF1-AS1 has also been shown to have potential as a drug target. The doublecortin gene has been shown to encode a protein involved in the detoxification of xenobiotics, which are harmful substances that can cause oxidative stress and inflammation in the body. The detoxification of xenobiotics is a critical function for maintaining cellular health and may be a potential therapeutic target for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

DMTF1-AS1 has been shown to interact with several protein partners, including the transcription factor PDGF-??1. The interaction between DMTF1-AS1 and PDGF-??1 suggests that the molecule may have a role in regulating cellular processes that are influenced by PDGF signaling. This interaction may also have implications for the development of diseases that are characterized by PDGF signaling abnormalities, such as cancer.

DMTF1-AS1 has been shown to have unique functions in the regulation of cellular processes, including drug response, metabolism, and neuroprotection. The molecule's unique exons and predicted localization in the ER and NPC suggest that it may play a significant role in the regulation of these cellular processes. Additionally, the molecule's interaction with PDGF-??1 suggests that it may have potential as a drug target or biomarker for a variety of diseases. Further research is needed to determine the full potential of DMTF1-AS1 as a drug target and biomarker.

Protein Name: DMTF1 Antisense RNA 1

The "DMTF1-AS1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DMTF1-AS1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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