Unlocking the Potential of DMAC1: A Potential Drug Target and Biomarker

Target Name: DMAC1

NCBI ID: G90871

DMAC1

Unlocking the Potential of DMAC1: A Potential Drug Target and Biomarker

Introduction

Distal membrane arm assembly complex 1 (DMAC1) is a protein that plays a crucial role in the regulation of actin dynamics and cell signaling. It is composed of four subunits: Dmc1, Dmc2, Dmc3, and Dmc4. DMAC1 functions by forming a complex with actinin, a protein that interacts with actin to regulate cell mechanical force and cytoskeletal dynamics. DMAC1 has been identified as a potential drug target and biomarker due to its unique structure, subcellular localization, and involvement in various cellular processes.

DMAC1's Subunits and Functions

DMAC1 is a four-subunit protein complex that consists of four subunits: Dmc1, Dmc2, Dmc3, and Dmc4. Each subunit has distinct functions in DMAC1's overall mechanism of action.

1. Dmc1: The first subunit is Dmc1, which is a 23-kDa protein that contains a N-terminal alpha-helicase domain and a C-terminal T-loop. Dmc1 functions as the N-terminal anchor of the DMAC1 complex, interacting with the actinin protein.
2. Dmc2: The second subunit is Dmc2, which is a 21-kDa protein that contains a N-terminal alpha-helicase domain and a C-terminal alpha-helix/beta-sheet domain. Dmc2 functions as the C-terminal anchor of the DMAC1 complex, interacting with the actinin protein.
3. Dmc3: The third subunit is Dmc3, which is a 17-kDa protein that contains a N-terminal alpha-helicase domain and a C-terminal alpha-helix/beta-sheet domain. Dmc3 functions as a molecular weight regulator of the DMAC1 complex, participating in the formation and disassembly of the complex.
4. Dmc4: The fourth subunit is Dmc4, which is a 12-kDa protein that contains a N-terminal alpha-helicase domain and a C-terminal alpha-sheet domain. Dmc4 functions as a molecular weight regulator of the DMAC1 complex, participating in the formation and disassembly of the complex.

DMAC1's Interaction with Actinin

DMAC1's interaction with actinin is a critical aspect of its function in regulating actin dynamics and cytoskeletal dynamics. Actinin is a protein that interacts with actin to regulate cell mechanical force and cytoskeletal dynamics. It contains a series of conserved domains, including a N-terminal alpha -helicase domain, a central 尾-sheet domain, and a C-terminal alpha-helix/beta-sheet domain.

DMAC1's N-terminal alpha-helicase domain interacts with actinin's N-terminal domain, allowing the two proteins to form a stable complex. The alpha-helicase domain of Dmc1 functions as a molecular rotor, allowing the complex to rotate and interact with actinin. This The interaction between Dmc1 and actinin is critical for the regulation of actin dynamics and cytoskeletal dynamics.

DMAC1's C-terminal alpha-sheet domain is involved in the regulation of the complex's stability and functions as a whole. The alpha-sheet domain contains multiple conserved helices that interact with actinin, contributing to the stability of the complex.

DMAC1's Role in Cellular Processes

DMAC1 is involved in various cellular processes, including cell signaling, cytoskeletal dynamics, and actin dynamics. It plays a

Protein Name: Distal Membrane Arm Assembly Component 1

Functions: Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I

The "DMAC1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DMAC1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets