Target Name: AGA
NCBI ID: G175
Review Report on AGA Target / Biomarker Content of Review Report on AGA Target / Biomarker
AGA
Other Name(s): glycosylasparaginase | N-aspartyl-beta -glucosaminidase | AGU | GA | N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase | aspartylglucosylamine deaspartylase | beta-aspartylglucosylamine amidohydrolase | ASRG | Aspartylglucosylamine deaspartylase | Glucosylamidase | Aspartylglucosylaminase | Aspartylglucosaminidase | Glycosylasparaginase | aspartylglucosaminidase | Aspartylglucosaminidase, transcript variant 1 | Glycosylasparaginase alpha chain | ASPG_HUMAN | N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase (isoform 1) | N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase | AGA variant 1 | Glycosylasparaginase beta chain

AGA: A Promising Drug Target / Biomarker

AGA (Alanine/Gluutamic Acid) is a molecule that has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Alanine and glutamic acid are both amino acids that are involved in the structure and function of proteins and have been linked to a number of physiological processes in the body.

The Potential Role of AGA in Cancer

One of the primary targets of AGA is its ability to inhibit the growth and survival of cancer cells. This is achieved through a variety of mechanisms, including the inhibition of the cell signaling pathway known as the PI3K/Akt pathway. This pathway is responsible for the delivery of nutrients and oxygen to cells and is a key factor in the development and progression of cancer. By inhibiting the PI3K/Akt pathway, AGA has been shown to reduce the growth and survival of cancer cells in both experimental models and human studies.

In addition to its role in cancer, AGA has also been shown to be involved in the regulation of cell division and apoptosis, which are also important factors in the development and progression of cancer. By regulating cell division and apoptosis, AGA has been shown to contribute to the development of cancer-like behaviors in a variety of cell lines and models.

The Potential Role of AGA in Neurodegenerative Disorders

AGA has also been shown to be involved in the development and progression of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. These disorders are characterized by the progressive loss of brain cells and are some of the most common causes of dementia and Parkinson's disease.

One of the key mechanisms by which AGA contributes to the development and progression of neurodegenerative disorders is its ability to cause oxidative stress in the brain. Oxidative stress is a state in which the levels of reactive oxygen species (ROS) in the brain becomeabnormal and can cause damage to brain cells and contribute to the development of neurodegenerative disorders.

In addition to its role in causing oxidative stress, AGA has also been shown to contribute to the development and progression of neurodegenerative disorders by its ability to regulate the expression of genes involved in neurodegeneration. For example, studies have shown that AGA can cause the expression of genes involved in the production of neurodegenerate proteins, such as beta-amyloid peptides, which are thought to contribute to the development of Alzheimer's disease.

The Potential Role of AGA in Autoimmune Diseases

AGA has also been shown to be involved in the development and progression of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. These disorders are characterized by the immune system attacking the body's own tissues and can cause a range of symptoms and disabilities.

One of the key mechanisms by which AGA contributes to the development and progression of autoimmune diseases is its ability to stimulate the production of immune cells in the body. This is achieved through its ability to stimulate the production of T-cells, which are a key component of the immune system. T-cells are responsible for helping the body fight off infections and are a key factor in the development and progression of autoimmune diseases.

In addition to its role in stimulating the production of immune cells, AGA has also been shown to contribute to the development and progression of autoimmune diseases by its ability to regulate the production of antibodies, which are a key component of the immune system. Abnormal production of antibodies can contribute to the development and progression of autoimmune diseases by causing the immune system to attack the body's own tissues.

Conclusion

AGA is a molecule that has been identified as a potential drug target and biomarker for a variety of diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Its ability to inhibit the growth and survival of cancer cells, contribute to the development and progression of

Protein Name: Aspartylglucosaminidase

Functions: Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins

The "AGA Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about AGA comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

AGA-DT | AGAP1 | AGAP1-IT1 | AGAP10P | AGAP11 | AGAP12P | AGAP14P | AGAP2 | AGAP2-AS1 | AGAP3 | AGAP4 | AGAP5 | AGAP6 | AGAP7P | AGAP9 | AGBL1 | AGBL2 | AGBL3 | AGBL4 | AGBL5 | AGER | AGFG1 | AGFG2 | AGGF1 | Aggrecanase | AGK | AGKP1 | AGL | AGMAT | AGMO | AGO1 | AGO2 | AGO3 | AGO4 | AGPAT1 | AGPAT2 | AGPAT3 | AGPAT4 | AGPAT4-IT1 | AGPAT5 | AGPS | AGR2 | AGR3 | AGRN | AGRP | AGS-16 | AGT | AGTPBP1 | AGTR1 | AGTR2 | AGTRAP | AGXT | AGXT2 | AHCTF1 | AHCTF1P1 | AHCY | AHCYL1 | AHCYL2 | AHCYP1 | AHCYP2 | AHDC1 | AHI1 | AHI1-DT | AHNAK | AHNAK2 | AHR | AHRR | AHSA1 | AHSA2P | AHSG | AHSP | AICDA | AIDA | AIDAP1 | AIF1 | AIF1L | AIFM1 | AIFM2 | AIFM3 | AIG1 | AIM2 | AIM2 Inflammasome | AIMP1 | AIMP2 | AIP | AIPL1 | AIRE | AJAP1 | AJM1 | AJUBA | AK1 | AK2 | AK2P2 | AK4 | AK4P1 | AK4P6 | AK5 | AK6 | AK6P1 | AK7