AGPAT4: Potential Drug Target Or Biomarker for Various Diseases

Target Name: AGPAT4

NCBI ID: G56895

AGPAT4

AGPAT4: Potential Drug Target Or Biomarker for Various Diseases

AGPAT4 (Lysophosphatidic acid acyltransferase-delta) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and gastrointestinal tract. It is a key enzyme in the synthesis of lysophosphatidic acid (LPA), a crucial signaling molecule that has been linked to a wide range of physiological processes. In recent years, research has identified AGPAT4 as a potential drug target or biomarker for a variety of diseases, including cardiovascular disease, neurodegenerative diseases, and cancer.

TheAGPAT4 enzyme is a member of the family of lipid-binding proteins, known as the P-type ATP-binding proteins (PABPs). These proteins are characterized by their ability to bind ATP and other nucleotides to their extracellular domains, allowing them to regulate various cellular processes, including protein synthesis, DNA replication, and signaling pathways. TheAGPAT4 enzyme is responsible for the synthesis of LPA, which is a key component of various cellular signaling pathways.

AGPAT4 has been shown to play a crucial role in the regulation of cellular processes that are involved in the development and progression of various diseases. For example, research has shown that AGPAT4 is involved in the regulation of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. These conditions are characterized by the progressive loss of brain cells and the development of neurofibrillary tangles, which are thought to contribute to the underlying causes of these diseases.

In addition to its role in neurodegenerative diseases, AGPAT4 has also been shown to be involved in the regulation of other important cellular processes, including cell signaling, DNA replication, and cell division. For example, studies have shown that AGPAT4 is involved in the regulation of cell proliferation and that it plays a role in the development of cancer.

AGPAT4 has also been shown to be involved in the regulation of cardiovascular disease. For example, research has shown that AGPAT4 is involved in the regulation of blood pressure and that it plays a role in the development of cardiovascular disease. This is thought to be because AGPAT4 is involved in the regulation of various factors that are involved in blood pressure regulation, including the contraction and dilation of blood vessels.

In addition to its potential role in drug targeting and disease pathology, AGPAT4 has also been identified as a potential biomarker for a variety of diseases. For example, research has shown that AGPAT4 is involved in the regulation of cellular processes that are involved in the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. These conditions are characterized by the progressive loss of brain cells and the development of neurofibrillary tangles, which are thought to contribute to the underlying causes of these diseases.

In conclusion, AGPAT4 is a protein that is expressed in various tissues throughout the body and is involved in the synthesis of lysophosphatidic acid (LPA), a crucial signaling molecule that has been linked to a wide range of physiological processes. Recent research has identified AGPAT4 as a potential drug target or biomarker for a variety of diseases, including cardiovascular disease, neurodegenerative diseases, and cancer. Further research is needed to fully understand the role of AGPAT4 in these diseases and to develop effective treatments.

Protein Name: 1-acylglycerol-3-phosphate O-acyltransferase 4

Functions: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA) (By similarity)

The "AGPAT4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about AGPAT4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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