AK1: The Enigma of Adenylate Kinase Isoenzyme 1 (G203)

Target Name: AK1

NCBI ID: G203

Content of Review Report on AK1 Target / Biomarker

AK1

AK1: The Enigma of Adenylate Kinase Isoenzyme 1

Adenylate kinase (AK) is a protein that plays a crucial role in various cellular processes, including metabolism, inflammation, and signaling pathways. It is an enzyme that catalyzes the transfer of a phosphate group from a phosphate donor to an amino acid residue, resulting in the formation of an adenylate molecule. This enzyme is highly conserved across various species, and its function has been extensively studied. One of the most fascinating aspects of AK is its potential as a drug target or biomarker. This article will explore the biology of AK1, its functions, and its potential as a drug target.

The Structure and Functions of AK1

AK1 is a 26kDa protein that consists of 216 amino acid residues. It has a unique structure, with a catalytic core and a distinct N-terminus and C-terminus. The catalytic core is composed of four conserved domains: a nucleotide-binding domain (NBD), a transmembrane domain (TMD), and a carboxy-terminal domain (CTD). The NBD and TMD are responsible for the protein's catalytic activity, while the CTD provides structural stability.

The functions of AK1 are numerous and diverse. It is involved in various cellular processes, including metabolism, inflammation, and signaling pathways. In metabolism, AK1 is involved in the citric acid cycle, which is a critical pathway for energy production. It is the rate-limiting step in the citric acid cycle, and its activity is regulated by various factors, including ATP and NAD+.

In inflammation, AK1 is involved in the production of reactive oxygen species (ROS), which contribute to the cellular stress and damage caused by inflammation. ROS can damage cellular components, including DNA, RNA, and proteins, leading to cellular dysfunction and death.

In signaling pathways, AK1 is involved in various signaling pathways, including G-protein-coupled receptors (GPCRs), which are involved in sensory perception and physiological processes. It is also involved in the production of chemokines, which are involved in the regulation of immune responses.

Potential as a Drug Target

The potential of AK1 as a drug target is significant due to its diverse functions and its involvement in various cellular processes. Several studies have suggested that AK1 may be a potential drug target due to its involvement in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

In cancer, AK1 has been shown to be involved in the regulation of cell growth, apoptosis, and angiogenesis. It has also been shown to play a role in the development of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In addition, AK1 has been implicated in the development and progression of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis.

Several studies have also suggested that AK1 may be a potential biomarker for various diseases. For example,AK1 has been shown to be elevated in the blood of patients with cancer, and its levels have been correlated with disease severity. Similarly,AK1 has been shown to be elevated in the urine of patients with neurodegenerative diseases, such as Alzheimer's disease.

The Potential of AK1 as a Drug Target

The potential of AK1 as a drug target is based on its involvement in various cellular processes and its potential functions as a drug target. Several studies have suggested that AK1 may be a potential drug target due to its involvement in various diseases.

In cancer, AK1 has been shown to be involved in the regulation of cell growth, apoptosis, and angiogenesis. It has also been shown to play

Protein Name: Adenylate Kinase 1

Functions: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP (PubMed:2542324). Exhibits nucleoside diphosphate kinase activity, catalyzing the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and dTTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor (PubMed:23416111). Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP (By similarity)

The "AK1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about AK1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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