SNAPIN in Cell Signaling, Growth, Differentiation and Metabolism

Target Name: SNAPIN

NCBI ID: G23557

SNAPIN

SNAPIN in Cell Signaling, Growth, Differentiation and Metabolism

SNAPIN (SPG-like protein gene 1) is a gene that encodes a protein known as SNAPIN. SNAPIN is a member of the BLOC-1 related complex subunit 3 family, which is a subfamily of the protein kinase superfamily. This family of proteins is involved in a variety of cellular processes, including cell signaling, DNA replication, and metabolism. SNAPIN is specifically involved in cell signaling, and is thought to play a role in the regulation of cell growth and differentiation.

SNAPIN is a 21-kDa protein that is expressed in a variety of tissues and cells. It is primarily localized to the cytoplasm of cells, but can also be found in the nucleus. SNAPIN is thought to be involved in the regulation of cell signaling, and is thus a potential drug target.

One of the key functions of SNAPIN is its role in the regulation of cell proliferation. In fact, SNAPIN has been shown to play a negative role in the regulation of cell growth and differentiation. Specifically, studies have shown that SNAPIN can inhibit the growth of cancer cells in cell culture and in animal models of cancer. This may have implications for the development of cancer therapies that target SNAPIN.

Another function of SNAPIN is its role in the regulation of cell differentiation. Specifically, SNAPIN has been shown to play a role in the regulation of stem cell stemness. This may have implications for the development of therapies that target SNAPIN to promote the differentiation of stem cells into functional tissues.

In addition to its role in cell signaling and cell growth, SNAPIN is also thought to be involved in the regulation of metabolism. Specifically, studies have shown that SNAPIN can interact with the protein known as SIRT1, which is involved in cellular stress response. This may have implications for the regulation of metabolism and the treatment of metabolic disorders.

SNAPIN is also a potential biomarker for a variety of diseases. For example, studies have shown that SNAPIN is downregulated in a variety of tissues and diseases, including cancer, neurodegenerative diseases, and metabolic disorders. This may have implications for the development of diagnostic tests and therapies based on SNAPIN levels or activity.

Overall, SNAPIN is a protein that is involved in a variety of cellular processes and is thus a potential drug target and biomarker. Further research is needed to fully understand the role of SNAPIN in cell signaling and metabolism, as well as its potential as a therapeutic target.

Protein Name: SNAP Associated Protein

Functions: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167)

The "SNAPIN Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SNAPIN comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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