SNHG29: A Non-Coding RNA Regulator of Gene Expression and Cellular Processes

Target Name: SNHG29

NCBI ID: G125144

SNHG29

SNHG29: A Non-Coding RNA Regulator of Gene Expression and Cellular Processes

SNHG29, also known as Small Nucleolar RNA Host Gene 29, is a gene that is located on chromosome 18q21. It is a non-coding RNA molecule that plays a critical role in the regulation of gene expression in the nucleus. SNHG29 is expressed in almost all human tissues and is involved in the regulation of various cellular processes, including cell growth, apoptosis, and transcriptional regulation.

SNHG29 is a key regulator of microRNA (miRNA) expression, which are small non-coding RNAs that play a critical role in post-transcriptional gene regulation. miRNA expression is regulated by a complex interplay of factors, including the translation of RNA molecules, the binding of RNA binding protein (RBP) to target RNAs, and the interactions between RNA and DNA. SNHG29 is one of the key transcription factors that can interact with miRNA RNA binding protein to regulate miRNA expression.

SNHG29 has been shown to play a critical role in the regulation of various cellular processes, including cell growth, apoptosis, and transcriptional regulation. For example, studies have shown that SNHG29 can promote the growth of human cancer cells and contribute to their survival. Additionally , SNHG29 has been shown to play a role in the regulation of cell apoptosis, which is a critical process for the elimination of damaged or dysfunctional cells.

SNHG29 has also been shown to be involved in the regulation of transcriptional expression of various genes. For example, studies have shown that SNHG29 can interact with the transcription factor, p53, to regulate the expression of the gene, p16. This interaction between SNHG29 and p53 suggests that SNHG29 may play a role in the regulation of p53-mediated gene expression.

In addition to its role in gene expression, SNHG29 has also been shown to play a critical role in the regulation of cellular processes, including cell adhesion and migration. For example, studies have shown that SNHG29 can interact with the protein, E-cadherin, to regulate the formation of tight junctions in epithelial cells. This interaction between SNHG29 and E-cadherin suggests that SNHG29 may play a role in the regulation of cell-cell adhesion and the regulation of cell migration.

SNHG29 has also been shown to play a role in the regulation of cellular signaling pathways. For example, studies have shown that SNHG29 can interact with the protein, FAK, to regulate the activity of the protein, Src. This interaction between SNHG29 and FAK suggests that SNHG29 may play a role in the regulation of FAK-mediated signaling pathways.

In conclusion, SNHG29 is a non-coding RNA molecule that plays a critical role in the regulation of gene expression in the nucleus. Studies have shown that SNHG29 is involved in the regulation of various cellular processes, including cell growth, apoptosis, and transcriptional regulation Additionally, SNHG29 has been shown to play a role in the regulation of cell adhesion and migration, as well as the regulation of cellular signaling pathways. Given its role in these processes, SNHG29 may be a potential drug target or biomarker for the development of various diseases. Further research is needed to fully understand the mechanisms of SNHG29's function in the nucleus and its potential as a drug target or biomarker.

Protein Name: Small Nucleolar RNA Host Gene 29

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