SNORA14B: A RNA-Binding Protein with Potential as A Drug Target Or Biomarker

Target Name: SNORA14B

NCBI ID: G677802

SNORA14B

Other Name(s): ACA14b | Small nucleolar RNA, H/ACA box 14B | small nucleolar RNA, H/ACA box 14B

SNORA14B: A RNA-Binding Protein with Potential as A Drug Target Or Biomarker

SNORA14B (ACA14b) is a protein that is expressed in various tissues of the body, including the brain, lungs, heart, and kidneys. It is a member of the superfamily of RNA-binding proteins, known as Nucleo-TranscriptionalRegulatoryProteins (NTRPs). SNORA14B is unique among its family members because of its ability to interact with the RNA polymerase II (RNA-pro) complex, which is responsible for transcribing DNA into RNA.

SNORA14B is a 21-kDa protein that consists of 14 constant and 2 variable regions. The variable regions are located at the C-terminus of the protein and contain several putative RNA-binding sites. These sites give SNORA14B the ability to interact with the RNA-pro complex.

The RNA-pro complex is a protein-protein interaction that is essential for the regulation of gene expression. It consists of several subunits, including the alpha subunit, which is a 28-kDa protein that contains a N-terminal transmembrane domain, and the beta subunit, which is a 19-kDa protein that contains a N-terminal transmembrane domain and a C-terminal alpha-helices region.

SNORA14B is able to interact with the alpha subunit of the RNA-pro complex because of its N-terminal transmembrane domain. This domain is known as a \"cytoplasmic domain\" and is located at the N-terminus of the protein. The cytoplasmic domain is involved in the interactions between SNORA14B and the RNA-pro complex.

In addition to its interaction with the RNA-pro complex, SNORA14B has also been shown to play a role in the regulation of gene expression. For example, studies have shown that SNORA14B can interact with the p53 protein, which is a well-known regulator of gene expression. This interaction between SNORA14B and p53 suggests that SNORA14B may be a potential drug target or biomarker for the treatment of p53-related diseases.

SNORA14B is also known to interact with the transcription factor, p16INK4a. This interaction between SNORA14B and p16INK4a suggests that SNORA14B may be a potential target for the inhibition of p16INK4a-mediated gene expression.

Furthermore, SNORA14B has also been shown to interact with the protein, heat shock protein (Hsp) HSP70. This interaction between SNORA14B and Hsp70 suggests that SNORA14B may be a potential target for the regulation of Hsp70-mediated protein folding and degradation.

In conclusion, SNORA14B is a unique protein that is involved in the regulation of gene expression. Its interaction with the RNA-pro complex and various other proteins suggests that it may be a potential drug target or biomarker for the treatment of a variety of diseases. Further research is needed to fully understand the role of SNORA14B in the regulation of gene expression and its potential as a drug target or biomarker.

Protein Name: Small Nucleolar RNA, H/ACA Box 14B

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