FPR3: A Potential Drug Target for Cancer and Neurodegenerative Diseases

Target Name: FPR3

NCBI ID: G2359

FPR3

FPR3: A Potential Drug Target for Cancer and Neurodegenerative Diseases

FPR3 (FMLP-R-II), a protein encoded by the gene FPR3, is a potential drug target and biomarker associated with various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. FPR3 is a member of the FPR family, which includes several evolutionarily conserved genes involved in the regulation of essential cellular processes, including cell adhesion, migration, and signaling pathways.

The FPR3 gene was first identified in 2008 as a potential gene involved in the development and progression of cancer. Since then, several studies have demonstrated the involvement of FPR3 in various cellular and biological processes, including the regulation of cell adhesion, migration, and the control of apoptosis. These findings have led to the hypothesis that FPR3 may be a drug target with potential for the treatment of cancer and other neurodegenerative diseases.

One of the key functions of FPR3 is its role in cell adhesion and migration. FPR3 is involved in the regulation of the actin cytoskeleton, which is essential for the maintenance of cell shape, integrity, and adhesion. In addition, FPR3 is involved in the regulation of cell migration, which is critical for the development and progression of cancer.

FPR3 has also been shown to play a role in the regulation of apoptosis, which is the process by which cells undergo programmed cell death. FPR3 has been shown to be involved in the regulation of apoptosis in various cellular contexts, including the regulation of neurodegenerative diseases.

In addition to its role in cell adhesion, migration, and apoptosis, FPR3 is also involved in the regulation of cell signaling pathways. FPR3 is a member of the FPR family, which includes several genes involved in the regulation of cellular signaling pathways, including the TGF-β pathway. This suggests that FPR3 may be involved in the regulation of cellular signaling pathways that are critical for the development and progression of cancer.

Given the involvement of FPR3 in various cellular and biological processes, it is a potential drug target with potential for the treatment of cancer and other neurodegenerative diseases. FPR3 has been shown to be involved in the regulation of cell adhesion, migration, and apoptosis, and has been shown to play a role in the regulation of cellular signaling pathways. Further research is needed to determine the full scope of FPR3's involvement in these processes and to develop effective treatments based on this understanding.

Protein Name: Formyl Peptide Receptor 3

Functions: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Acts as a receptor for humanin (PubMed:15465011)

The "FPR3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FPR3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets