FERM Domain as Potential Drug Target for Neurodegenerative Diseases

Target Name: FRMD4B

NCBI ID: G23150

FRMD4B

FERM Domain as Potential Drug Target for Neurodegenerative Diseases

The FERM domain containing 4B (Fe- rich naphthalene-1,4-carboxylic acid) is a protein that has been identified as a potential drug target (or biomarker) in the field of neurodegenerative diseases. The FERM domain is a small protein that is characterized by the presence of a distinct N-terminal region that contains a conserved core domain and a carboxylic acid region. The N-terminal region contains a putative transmembrane domain (TMD) that is involved in the protein's localization and stability, while the carboxylic acid region is involved in the protein's catalytic activity.

One of the unique features of the FERM domain is its ability to interact with various chemical entities, including small molecules, peptides, and even entire proteins. This interactivity makes the FERM domain a potentially promising drug target, as it allows it to participate in a wide range of cellular processes that are involved in the development and progression of neurodegenerative diseases.

Recent studies have suggested that the FERM domain containing 4B may be involved in the development and progression of a number of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. For example, studies have shown that the FERM domain containing 4B is expressed in the brains of individuals with Alzheimer's disease and that it is involved in the production of amyloid peptides, which are thought to contribute to the development of this disease.

Another study has suggested that the FERM domain containing 4B may be involved in the development of Parkinson's disease. This study found that the FERM domain containing 4B was expressed in the brains of individuals with Parkinson's disease and that it was involved in the production of dopamine, a neurotransmitter that is thought to be involved in the progression of this disease.

In addition to its potential involvement in neurodegenerative diseases, the FERM domain containing 4B has also been shown to have potential as a drug target. Studies have shown that the FERM domain containing 4B can interact with small molecules, including drugs that are currently being used to treat neurodegenerative diseases. For example, one study found that the FERM domain containing 4B can interact with the drug tau-targeted kinase (TAT) inhibitor BHV-550, which is being used to treat Alzheimer's disease.

Another study has suggested that the FERM domain containing 4B may be involved in the development of neurodegenerative diseases by contributing to the production of pro-inflammatory molecules. This study found that the FERM domain containing 4B was involved in the production of pro-inflammatory cytokines, which are thought to contribute to the development of neurodegenerative diseases.

Overall, the FERM domain containing 4B is a protein that has been identified as a potential drug target (or biomarker) in the field of neurodegenerative diseases. Its unique ability to interact with a wide range of chemical entities and its involvement in the development and progression of these diseases make it an attractive target for future research. Further studies are needed to fully understand the role of the FERM domain containing 4B in neurodegenerative diseases and to develop effective treatments.

Protein Name: FERM Domain Containing 4B

Functions: Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization

The "FRMD4B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FRMD4B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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