FSHR: Potential Drug Target and Biomarker (G2492)

Target Name: FSHR

NCBI ID: G2492

FSHR

FSHR: Potential Drug Target and Biomarker

Follicle stimulating hormone (FSH) is a hormone produced by the pituitary gland that plays a crucial role in the growth and development of hair, as well as the regulation of sexual behavior in humans. FSH is a protein that consists of two subunits, FSHR1 and FSHR2, which are encoded by the genes FSHR1 and FSHR2, respectively.

FSHR has been extensively studied for its role in various biological processes, including the regulation of hair growth and density, the timing of sexual behavior, and the development and progression of certain diseases. In recent years, researchers have also been interested in exploring the potential use of FSHR as a drug target or biomarker.

Drug Target Potential

FSHR has been identified as a potential drug target due to its involvement in various cellular processes that are associated with the development and progression of various diseases. One of the main targets of FSHR is the regulation of hair growth and density. FSHR plays a critical role in the development of new hair follicles and the growth of existing ones, and mutations in the FSHR gene have been linked to various hair growth disorders, including alopecia areata and androgen-dependent agouti syndrome.

In addition to its role in hair growth, FSHR has also been shown to be involved in the regulation of sexual behavior andlibidinal function. FSHR is a key regulator of sexual behavior in male humans, and mutations in the FSHR gene have been linked to various sexual disorders, including hypogonadism and decreased libido.

Biomarker Potential

FSHR has also been identified as a potential biomarker for several diseases, including cancer. FSHR has been shown to be involved in the regulation of cell proliferation and apoptosis, which are important processes that are altered in many types of cancer. Additionally, FSHR has also been shown to play a role in the regulation of angiogenesis, which is the process by which new blood vessels form in the body. This is important in the development of many types of cancer, including breast and prostate cancer.

Mutations in the FSHR gene have also been linked to various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and depression. These mutations have been shown to disrupt the normal function of FSHR and contribute to the development of these disorders.

Pathway Analysis

FSHR has been shown to play a role in several intracellular signaling pathways that are involved in various cellular processes, including cell proliferation, apoptosis, angiogenesis, and intracellular signaling.

In addition to its role in intracellular signaling, FSHR has also been shown to play a role in the regulation of cellular interactions with the surrounding environment, including the regulation of cell adhesion and the formation of tight junctions.

Conclusion

FSHR is a protein that is involved in a wide range of cellular processes that are important in the growth and development of hair, as well as the regulation of sexual behavior in humans. FSHR has also been identified as a potential drug target and biomarker for various diseases, including cancer and neurological and psychiatric disorders. Further research is needed to fully understand the role of FSHR in these processes and to explore its potential as a drug.

Protein Name: Follicle Stimulating Hormone Receptor

Functions: G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (PubMed:24058690)

The "FSHR Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FSHR comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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