PATZ1: A Zinc Finger and BTB Domain-Containing Protein and Its Potential as a Drug Target

Target Name: PATZ1

NCBI ID: G23598

PATZ1

PATZ1: A Zinc Finger and BTB Domain-Containing Protein and Its Potential as a Drug Target

Abstract:

PATZ1 (Zinc Finger and BTB Domain-Containing Protein 19) is a protein that has been identified as a potential drug target and biomarker. It is a zinc finger protein and belongs to the BTB domain family. PATZ1 has been shown to play a role in various cellular processes, including cell growth, differentiation, and survival. Its unique structure and function make it an attractive target for drug development.

Introduction:

PATZ1 (Zinc Finger and BTB Domain-Containing Protein 19) is a protein that was identified as a potential drug target and biomarker. It is a zinc finger protein and belongs to the BTB domain family. Zinc finger proteins are a type of transmembrane protein that contain a nucleotide-binding domain and a zinc finger domain. They are involved in various cellular processes, including cell growth, differentiation, and survival.

PATZ1: Structure and Function:

PATZ1 has a unique structure that consists of a nucleotide-binding domain, a zinc finger domain, and a cytoplasmic tail. The nucleotide-binding domain is responsible for binding to nucleotides, while the zinc finger domain interacts with the cytoplasmic tail to ensure stability of the protein. The cytoplasmic tail is involved in the protein's stability and localization to the cytoplasm.

PATZ1 has been shown to play a role in various cellular processes, including cell growth, differentiation, and survival. For example, studies have shown that PATZ1 is involved in the regulation of cell cycle progression, cell adhesion, and the response to chemotherapy. It has also been shown to interact with various signaling pathways, including the PI3K/Akt signaling pathway.

PATZ1 as a drug target:

PATZ1 is a potential drug target due to its unique structure and function. Its zinc finger domain and BTB domain make it an attractive target for small molecules that can modulate its activity. Studies have shown that inhibitors of PATZ1 can inhibit the growth and survival of cancer cells. This suggests that PATZ1 may be an effective target for cancer treatment.

PATZ1 as a biomarker:

PATZ1 has also been shown to be a potential biomarker for various diseases, including cancer. Its involvement in the regulation of cellular processes makes it an attractive target for diagnostic tools. Studies have shown that changes in PATZ1 levels can be associated with the development and progression of cancer. This suggests that PATZ1 may be a useful biomarker for cancer diagnosis and treatment.

Conclusion:

PATZ1 (Zinc Finger and BTB Domain-Containing Protein 19) is a protein that has been identified as a potential drug target and biomarker. Its unique structure and function make it an attractive target for small molecules that can modulate its activity. Studies have shown that inhibitors of PATZ1 can inhibit the growth and survival of cancer cells, making it a promising target for cancer treatment. Its involvement in the regulation of cellular processes also makes it an attractive biomarker for diagnostic tools. Further research is needed to fully understand the potential of PATZ1 as a drug target and biomarker.

Protein Name: POZ/BTB And AT Hook Containing Zinc Finger 1

Functions: Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis (PubMed:10713105, PubMed:25755280, PubMed:31875552). Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53 (PubMed:25755280). Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions (PubMed:31875552)

The "PATZ1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PATZ1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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