PCCB: Enzyme Involved in Crucial Metabolism and Regulation (G5096)

Target Name: PCCB

NCBI ID: G5096

PCCB

Other Name(s): propionyl CoA carboxylase, beta polypeptide | propionyl Coenzyme A carboxylase, beta polypeptide | Propionyl-CoA carboxylase beta chain, mitochondrial (isoform 2) | propionyl-CoA carboxylase subunit beta | Propionyl-CoA carboxylase subunit beta, transcript variant 1 | PCCB variant 2 | Propionyl-CoA carboxylase beta chain, mitochondrial | Propanoyl-CoA:carbon dioxide ligase subunit beta | PCCB_HUMAN | PCCase subunit beta | Propionyl-CoA carboxylase beta chain, mitochondrial (isoform 1) | Propionyl-CoA carboxylase subunit beta, transcript variant 2 | PCCB variant 1 | DKFZp451E113 | Propionyl Coenzyme A carboxylase, beta polypeptide | propionyl-CoA carboxylase beta subunit | propanoyl-CoA:carbon dioxide ligase subunit beta

PCCB: Enzyme Involved in Crucial Metabolism and Regulation

Propionyl CoA carboxylase (PCCB) is an enzyme involved in the metabolism of propionylCoA, a crucial intermediate in the citric acid cycle, also known as the Krebs cycle or tricarboxylic acid (TCA) cycle. PCCB is a protein that belongs to the family of enzymes Known as coenzyme A carboxylases (CACs) and is expressed in various tissues throughout the body. Its primary function is to catalyze the conversion of propionylCoA to acetyl-CoA, which is then used to produce energy in the form of ATP.

PCCB is a critical enzyme in the citric acid cycle, as it helps to regulate the rate at which acetyl-CoA is produced. The production of acetyl-CoA is essential for the synthesis of many essential amino acids, including leucine, which is vital for muscle growth and repair. In addition, the production of acetyl-CoA is also critical for the production of ketones, which are important energy sources for the brain.

PCCB is also involved in the regulation of the citric acid cycle in the liver. The liver is the primary site of PCCB expression, and it is there that the enzyme is primarily involved in the metabolism of fatty acids. PCCB helps to regulate the production of acyl-CoA, which is then used to produce fatty acids, such as omega-3 and omega-6 fatty acids.

PCCB is a protein that is expressed in various tissues throughout the body, including the brain, liver, and kidneys. It is primarily localized to the endoplasmic reticulum (ER), which is the protein synthesis and modification site. PCCB is also known to be involved in the regulation of protein synthesis, and it has been shown to play a role in the regulation of various cellular processes, including cell growth, apoptosis, and inflammation.

In addition to its role in the citric acid cycle, PCCB is also a potential drug target. The development of PCCB inhibitors has been shown to have therapeutic potential in a variety of diseases, including cancer, neurodegenerative diseases, and obesity.

PCCB inhibitors have been shown to have anti-inflammatory effects. PCCB is a key enzyme in the production of reactive oxygen species (ROS), which are highly reactive molecules that can cause damage to cellular components and contribute to the development of various diseases, including cancer. By inhibiting PCCB, researchers have been shown to be able to reduce the production of ROS and improve the health of tissues.

In addition to its anti-inflammatory effects, PCCB inhibitors have also been shown to have anti-cancer effects. The production of ROS is a well-established mechanism for the development of cancer, and PCCB has been shown to play a role in the production of ROS. By inhibiting PCCB, researchers have been able to reduce the production of ROS and improve the health of cancer cells.

PCCB inhibitors have also been shown to have neuroprotective effects. The production of ROS is a well-established mechanism for the development of neurodegenerative diseases, and PCCB has been shown to play a role in the production of ROS. By inhibiting PCCB, researchers have been able to reduce the production of ROS and improve the health of neural cells.

In addition to its anti-inflammatory and neuroprotective effects, PCCB inhibitors have also been shown to have a positive impact on body weight. The production of ROS is a well-established mechanism for the production of fat, and PCCB has been shown to play a role in the production of ROS. By inhibiting PCCB, researchers have been able to reduce the production of ROS and improve the health of tissues, including those responsible for maintaining

Protein Name: Propionyl-CoA Carboxylase Subunit Beta

Functions: This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites (PubMed:6765947, PubMed:15890657). Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (PubMed:6765947, PubMed:15890657). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate (PubMed:6765947). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity)

The "PCCB Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PCCB comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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