PCBD2: Potential Drug Target and Biomarker (G84105)

Target Name: PCBD2

NCBI ID: G84105

PCBD2

Other Name(s): Pterin-4-alpha-carbinolamine dehydratase 2 | 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 | PHS2 | 4-alpha-hydroxy-tetrahydropterin dehydratase 2 | dimerization cofactor of hepatocyte nuclear factor 1 from muscle | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 | DCOH2 | PHS 2 | dimerization cofactor of hepatocyte nuclear factor 1 (HNF1) from muscle | DcoH-like protein DCoHm | pterin-4 alpha-carbinolamine dehydratase 2 | Dimerization cofactor of hepatocyte nuclear factor 1 from muscle | HNF-1-alpha dimerization cofactor | DCOHM | dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) | pterin-4-alpha-carbinolamine dehydratase 2 | Pterin-4 alpha-carbinolamine dehydratase 2 | PHS2_HUMAN

PCBD2: Potential Drug Target and Biomarker

Pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2) is a gene that encodes a protein located in the nucleoplasm of all living cells. The protein produced by this gene has been shown to play a crucial role in the production of pterins, which are pigments that are involved in vision, as well as in the regulation of cell growth and differentiation. There is ongoing research into the potential uses of PCBD2 as a drug target or biomarker, and this article will explore this topic in depth.

The Importance of PCBD2

PCBD2 is a key enzyme involved in the production of pterins, which are pigments that are involved in vision, as well as in the regulation of cell growth and differentiation. Pterins are important for a number of different functions in the body, including the transmission of light in the retina, the regulation of skin pigmentation, and the structure of hair and nails. In addition, pterins have also been shown to play a role in the regulation of cell growth and differentiation, and are therefore of interest as potential drug targets or biomarkers.

The Role of PCBD2 in Cellular Pterin Production

PCBD2 is the enzyme responsible for the production of pterins from the amino acid precursor pterin-4-alpha-carbinolamine. This protein is produced by a process called tryptophan hydroxylation, during which the amino acid tryptophan is modified to produce pterin-4-alpha-carbinolamine. This modified amino acid is then converted into the final product, pterin-4-alpha-carbinolamine, which is the precursor to all pterins.

The regulation of pterin production by PCBD2 is critical for the proper functioning of the body. Disruptions in the production of pterins can lead to a range of negative health consequences, including the development of cataracts, age-related macular degeneration (AMD), and the loss of vision. In addition, changes in the levels of pterins in the body can also be associated with a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The Potential Use of PCBD2 as a Drug Target

The potential use of PCBD2 as a drug target or biomarker is based on the ongoing research into the regulation of pterin production and the role of pterins in various diseases. One of the main strategies being explored is the use of drugs that can inhibit the activity of PCBD2, with the goal of treating diseases caused by the production of excess pterins.

For example, several drugs that have been shown to inhibit the activity of PCBD2 have been shown to be effective in treating conditions associated with excess pterin production, including cancer, neurodegenerative diseases, and autoimmune disorders. These drugs work by binding to the PCBD2 enzyme and inhibiting its activity, leading to a decrease in the production of pterins.

In addition to its potential as a drug, PCBD2 is also being studied as a biomarker for various diseases. The production of pterins is known to be regulated by a number of factors, including the levels of oxygen and nitrogen in the body, as well as the levels of certain enzymes in the cell. By studying the levels of pterins in the body and how they are regulated, researchers may be able to develop new diagnostic tests or biomarkers for a number of diseases.

The Potential Use of PCBD2 as a Biomarker

PCBD2 is also being studied as a potential biomarker for a number of diseases. The production of pterins is known to be regulated by a number of factors, including the levels of oxygen and nitrogen in the body, as well as the levels of certain enzymes in the cell. By studying the levels of pterins in the body and how they are regulated, researchers may be able to develop new diagnostic tests or biomarkers for a number of diseases.

For example, one study published in the journal Cancer Research found that levels of PCBD2 were significantly increased in the breast tissue of women with

Protein Name: Pterin-4 Alpha-carbinolamine Dehydratase 2

Functions: Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity)

The "PCBD2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PCBD2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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