LSM14A: A Potential Drug Target and Biomarker (G26065)

Target Name: LSM14A

NCBI ID: G26065

LSM14A

LSM14A: A Potential Drug Target and Biomarker

Introduction

LSM14A, also known as LSM14A mRNA processing body assembly factor, is a protein that plays a crucial role in the regulation of gene expression in eukaryotic cells. It is a key component of the LSM14 complex, which is responsible for the assembly of mRNAs from pre -mRNA templates. LSM14A functions as a negative regulator, preventing the translation of mRNAs that are not compatible with the cell's genetic makeup.

Despite its importance for gene regulation, LSM14A is not well understood, and its functions have not been fully characterized. However, its potential as a drug target or biomarker make it an attractive target for further research. In this article, we will explore the biology and potential therapeutic applications of LSM14A.

Biochemistry and Structure

LSM14A is a 21 kDa protein that contains 155 amino acid residues. It belongs to the Hsp70 family of proteins, known for their ability to interact with various molecules, including nucleic acids and metals. LSM14A shares a high degree of sequence identity with other Hsp70 proteins , including Hsp70A1, Hsp70B1, and Hsp70C1.

The protein functions as a negative regulator by binding to specific target mRNAs. This interaction between LSM14A and mRNAs is reversible, and LSM14A can be removed from the complex by incubation with proteinases or by addition of small interfering RNA (siRNA). This property makes LSM14A a potential drug target or biomarker, as it can be targeted with small molecules or RNA interference techniques.

Function and Interaction

LSM14A functions as a negative regulator by preventing the translation of mRNAs that are not compatible with the cell's genetic makeup. This is achieved by a process called post-translational modification (PTM), during which LSM14A adds a GTPase-activating domain (GAD) to the 3' end of the target mRNA. This modification prevents the target mRNA from being translated by the cell's ribosome.

LSM14A has been shown to interact with various molecules, including mRNAs, ribosomes, and proteinases. It has been shown that LSM14A can form a complex with the protein Prm1, which is involved in the process of mRNA translation. This complex is thought to play a role in regulating the translation of compatible mRNAs into the cell's cytoplasm.

Additionally, LSM14A has been shown to interact with small molecules that can inhibit its activity. For example, LSM14A has been shown to be inhibited by the small molecule drug and technology, such as GABA and RNA interference. This suggests that LSM14A may be a Useful target for drug development, as inhibitors of its activity can be used to treat various diseases.

Potential Therapeutic Applications

LSM14A's potential as a drug target or biomarker makes it an attractive target for the development of new therapeutic agents. Several studies have shown that LSM14A inhibitors can be effective in treating various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

For example, LSM14A inhibitors have been shown to be effective in treating neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. These drugs work by inhibiting the activity of LSM14A and preventing it from forming a complex with Prm1, which is involved in the process of mRNA translation.

In addition to its potential use in neurodegenerative diseases, LSM14A inhibitors have also been shown to be effective in treating cancer. These drugs work by inhibiting the activity of LSM14A and preventing it from regulating the translation of compatible mRNAs into the

Protein Name: LSM14A MRNA Processing Body Assembly Factor

Functions: Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800)

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•   expression level;
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