Discovering Potential Drug Targets for AFF4 Protein (G27125)

Target Name: AFF4

NCBI ID: G27125

AFF4

Discovering Potential Drug Targets for AFF4 Protein

AFF4 (AF5Q31) is a protein that is expressed in various tissues throughout the body, including the brain, heart, kidneys, and liver. It is a key regulator of cell growth and differentiation, and has been implicated in a number of diseases, including neurodegenerative disorders, cancer, and autoimmune diseases.

One of the most promising aspects of AFF4 is its potential as a drug target. Researchers have identified several potential binding sites on AFF4 that could be targeted by small molecules, antibodies, or other therapeutic agents. These sites include the N-terminus, C- terminus, and interior region of the protein, as well as a potential N-loop region near the protein's C-terminus.

One of the most promising potential drug targets for AFF4 is its role in the development and progression of neurodegenerative disorders. AFF4 has been shown to be involved in the regulation of the neurotransmitter dopamine, which is involved in a number of important brain functions, including motivation , pleasure, and mood regulation.

In addition to its role in neurodegenerative disorders, AFF4 is also thought to be involved in the development and progression of a number of other diseases, including cancer and autoimmune diseases. This makes it an attractive target for drug development in a variety of settings.

The potential benefits of AFF4 as a drug target are significant. In the context of neurodegenerative disorders, AFF4 has the potential to treat a range of symptoms, including tremors, rigidity, and decline in cognitive function. In the context of cancer and autoimmune diseases, AFF4 has the potential to target tumors and immune cells that have been shown to be aberrant or hyperactive in these conditions.

In addition to its potential therapeutic applications, AFF4 is also an important protein for basic research into cell biology and development. By studying the regulation of AFF4, researchers are able to gain insights into the complex mechanisms of cell growth and differentiation, and to identify new targets for drug development.

Overall, AFF4 is a protein that has significant potential as a drug target, and is an important area of 鈥嬧?媟esearch in the fields of neurodegenerative disorders, cancer, and autoimmune diseases. Further studies are needed to fully understand the role of AFF4 in these conditions, and to identify the most effective treatments.

Protein Name: ALF Transcription Elongation Factor 4

Functions: Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression

The "AFF4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about AFF4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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