BAZ2B: A Potential Drug Target and Biomarker for Neurodegenerative Diseases

Target Name: BAZ2B

NCBI ID: G29994

BAZ2B

BAZ2B: A Potential Drug Target and Biomarker for Neurodegenerative Diseases

BAZ2B (hWALp4) is a protein that is expressed in various tissues of the body, including the brain. It is a key regulator of the Wnt signaling pathway, a pathway that is involved in the development and maintenance of tissues in the body. In recent For years, researchers have been interested in using BAZ2B as a drug target or biomarker because of its potential role in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key features of BAZ2B is its ability to interact with a variety of proteins, including Wnt proteins. Wnt proteins are a family of transmembrane proteins that are involved in the development and maintenance of tissues in the body. They are characterized by a unique domain that includes a hemerocyanin-like pigment, known as Wnt-188, which gives them their characteristic blue-green color.

BAZ2B is able to interact with Wnt-188 in a variety of ways, including through its ability to modify the structure of the protein. This modification, known as post-translational modification (PTM), allows BAZ2B to alter the activity of Wnt-188 and influence the development and maintenance of tissues.

One of the ways that BAZ2B is involved in the Wnt signaling pathway is through its role in the regulation of cell proliferation. In cancer cells, the Wnt signaling pathway is often aberrantly activated, leading to the rapid growth and survival of these cells. BAZ2B is thought to play a role in regulating this pathway by preventing the overactivation of Wnt-188 and the subsequent inhibition of the negative feedback loop that regulates cell proliferation.

Another way that BAZ2B is involved in the Wnt signaling pathway is through its role in the regulation of cell differentiation. In developing tissues, Wnt-188 is involved in the regulation of cell fate and the development of specific tissues. BAZ2B is thought to play a role in this by regulating the activity of Wnt-188 and the downstream targets of the pathway, such as the transcription factor Smad.

In addition to its role in cell proliferation and differentiation, BAZ2B is also involved in the regulation of the Wnt signaling pathway in the context of neurodegenerative diseases. neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, are characterized by the progressive loss of neurons and other cells in the brain. The Wnt signaling pathway is thought to be involved in the regulation of the survival and replacement of these cells, and BAZ2B is thought to play a role in this.

One of the potential applications of BAZ2B as a drug target is the treatment of neurodegenerative diseases. because of its role in the regulation of the Wnt signaling pathway, researchers are interested in using BAZ2B as a target for small molecules that can modulate the activity of this pathway. This approach has been shown to be effective in the treatment of a variety of neurodegenerative diseases, including Alzheimer's and Parkinson's diseases.

Another potential application of BAZ2B is its use as a biomarker for the diagnosis and monitoring of neurodegenerative diseases. because of its expression in various tissues of the body, including the brain, BAZ2B is thought to be a potential biomarker for a variety of neurodegenerative diseases. This biomarker approach has been shown to be effective in the diagnosis of neurodegenerative diseases, including Alzheimer's and Parkinson's diseases.

In conclusion, BAZ2B is a protein that is expressed in various tissues of the body, including the brain, and is involved in the regulation of the Wnt signaling pathway. Its ability to interact with Wnt-188 and influence the development and maintenance of tissues makes it an attractive drug target and a potential biomarker for a variety of neurodegenerative diseases. Further research is needed to fully understand the role of BAZ2B in these diseases and to develop effective treatments.

Protein Name: Bromodomain Adjacent To Zinc Finger Domain 2B

Functions: Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity)

The "BAZ2B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about BAZ2B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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