IGF2R: A Protein Regulator of Cell Growth and Metabolism (G3482)

Target Name: IGF2R

NCBI ID: G3482

IGF2R

IGF2R: A Protein Regulator of Cell Growth and Metabolism

The Insulin-like growth factor 2 receptor (IGF2R) is a protein that is found on the surface of certain cells in the body. It is a key regulator of cell growth and has been implicated in a number of diseases, including obesity, type 2 diabetes, and cancer. In recent years, researchers have been investigating the potential of using IGF2R as a drug target or biomarker for a variety of diseases.

One of the main reasons for the interest in IGF2R is its ability to regulate cell growth and metabolism. IGF2R plays a role in the development and maintenance of tissues and organs, including muscle, bone, and fat cells. It also helps to control the growth of cancer cells and has been shown to be involved in the development of certain types of cancer.

In addition to its role in cell growth and cancer, IGF2R has also been shown to play a key role in the regulation of metabolism and energy balance. It helps to control the levels of glucose in the body and has been shown to be involved in the regulation of insulin sensitivity. IGF2R has also been shown to play a role in the regulation of cell death and has been shown to have anti-inflammatory effects.

As a drug target, IGF2R has the potential to be used to treat a variety of diseases, including obesity, type 2 diabetes, and certain types of cancer. For example, some researchers have been investigating the use of IGF2R inhibitors as a treatment for obesity, with some studies showing that these inhibitors can lead to significant weight loss in obese individuals. IGF2R has also been shown to be involved in the regulation of blood sugar levels and has been investigated as a potential treatment for type 2 diabetes. In addition, IGF2R has been shown to have anti-inflammatory effects and has been investigated as a potential treatment for certain types of cancer.

As a biomarker, IGF2R has the potential to be used as a diagnostic tool for a variety of diseases. For example, some researchers have been investigating the use of IGF2R as a potential biomarker for cancer, with some studies showing that IGF2R levels can be significantly elevated in the blood of individuals with certain types of cancer. IGF2R has also been shown to be involved in the regulation of cell growth and has been used as a potential biomarker for a variety of other diseases, including cardiovascular disease and neurological disorders.

In conclusion, IGF2R is a protein that plays a key role in the regulation of cell growth and metabolism. As a drug target, IGF2R has the potential to be used to treat a variety of diseases, including obesity, type 2 diabetes, and certain types of cancer. As a biomarker, IGF2R has the potential to be used as a diagnostic tool for a variety of diseases. Further research is needed to fully understand the role of IGF2R in the regulation of cell growth and metabolism and to explore its potential as a drug or biomarker.

Protein Name: Insulin Like Growth Factor 2 Receptor

Functions: Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:2963003, PubMed:18817523). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:2963003, PubMed:18817523). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005)

The "IGF2R Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IGF2R comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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